Identifying molecular features that distinguish fluvastatin-sensitive breast tumor cells.

Breast Cancer Research and Treatment
Carolyn A GoardLinda Z Penn

Abstract

Statins, routinely used to treat hypercholesterolemia, selectively induce apoptosis in some tumor cells by inhibiting the mevalonate pathway. Recent clinical studies suggest that a subset of breast tumors is particularly susceptible to lipophilic statins, such as fluvastatin. To quickly advance statins as effective anticancer agents for breast cancer treatment, it is critical to identify the molecular features defining this sensitive subset. We have therefore characterized fluvastatin sensitivity by MTT assay in a panel of 19 breast cell lines that reflect the molecular diversity of breast cancer, and have evaluated the association of sensitivity with several clinicopathological and molecular features. A wide range of fluvastatin sensitivity was observed across breast tumor cell lines, with fluvastatin triggering cell death in a subset of sensitive cell lines. Fluvastatin sensitivity was associated with an estrogen receptor alpha (ERα)-negative, basal-like tumor subtype, features that can be scored with routine and/or strong preclinical diagnostics. To ascertain additional candidate sensitivity-associated molecular features, we mined publicly available gene expression datasets, identifying genes encoding regulators of mevalonat...Continue Reading

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Citations

Jan 9, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Annemarie GreifeJiri Hatina
Jun 12, 2016·Breast Cancer Research and Treatment·Banu K ArunNour Sneige
Oct 25, 2016·Nature Reviews. Cancer·Peter J MullenLinda Z Penn
Mar 24, 2020·Prostate Cancer and Prostatic Diseases·Joseph LongoLinda Z Penn
Apr 6, 2017·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Signe BorgquistBeat Thürlimann
Sep 5, 2019·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Joanna M KarasinskaDavid F Schaeffer
Sep 6, 2020·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Joseph LongoLinda Z Penn
Apr 5, 2015·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Olöf BjarnadottirSigne Borgquist
Sep 15, 2020·Biochimica Et Biophysica Acta. Molecular Basis of Disease·Mazaher AhmadiSaeid Ghavami
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Mar 16, 2021·Frontiers in Oncology·Borja GuerraLeandro Fernández-Pérez
Oct 18, 2021·Veterinary and Comparative Oncology·Takuro IshikawaKatsuhiko Warita

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