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Identifying mutual exclusivity across cancer genomes: computational approaches to discover genetic interaction and reveal tumor vulnerability

Briefings in Bioinformatics

Oct 3, 2017

Yulan DengXia Li

Abstract

Systematic sequencing of cancer genomes has revealed prevalent heterogeneity, with patients harboring various combinatorial patterns of genetic alteration. In particular, a phenomenon that a group of genes exhibits mutually exclusive patterns has been widespread across cancers, covering...read more

Mentioned in this Paper

In Silico
Biochemical Pathway
Gene Expression Regulation, Neoplastic
Patterns
Genome
Genes
Genomic Profile
Neoplasms
Tumor Initiation
Selex Aptamer Technique
3
25
Paper Details
References
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  • References82
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Identifying mutual exclusivity across cancer genomes: computational approaches to discover genetic interaction and reveal tumor vulnerability

Briefings in Bioinformatics

Oct 3, 2017

Yulan DengXia Li

PMID: 28968730

DOI: 10.1093/bib/bbx109

Abstract

Systematic sequencing of cancer genomes has revealed prevalent heterogeneity, with patients harboring various combinatorial patterns of genetic alteration. In particular, a phenomenon that a group of genes exhibits mutually exclusive patterns has been widespread across cancers, covering...read more

Mentioned in this Paper

In Silico
Biochemical Pathway
Gene Expression Regulation, Neoplastic
Patterns
Genome
Genes
Genomic Profile
Neoplasms
Tumor Initiation
Selex Aptamer Technique
3
25

Similar Papers Found In These Feeds

ncRNAs in Health and Disease (Keystone)

Non-coding RNAs (ncRNAs) are RNA molecules that do not code for protein, but can have functional roles in regulating gene expression at the transcriptional and post-transcriptional level. Discover the latest research on the role of ncRNAs in health and disease.

Cancer Genomics (Keystone)

Cancer genomics approaches employ high-throughput technologies to identify the complete catalog of somatic alterations that characterize the genome, transcriptome and epigenome of cohorts of tumor samples. Discover the latest research using such technologies in this feed.

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Journal of Computational Biology : a Journal of Computational Molecular Cell Biology

On the Sample Complexity of Cancer Pathways Identification

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Fabio VandinEli Upfal
Paper Details
References
  • References82
  • Citations1
12345...
  • References82
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1
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