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Identifying mutual exclusivity across cancer genomes: computational approaches to discover genetic interaction and reveal tumor vulnerability

Briefings in Bioinformatics

Jan 18, 2019

Yulan DengXia Li

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Abstract

Systematic sequencing of cancer genomes has revealed prevalent heterogeneity, with patients harboring various combinatorial patterns of genetic alteration. In particular, a phenomenon that a group of genes exhibits mutually exclusive patterns has been widespread across cancers, covering...read more

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  • Identifying mutual exclusivity across cancer genomes: computational approaches to discover genetic interaction and reveal tumor vulnerability

    Briefings in Bioinformatics

    Jan 18, 2019

    Yulan DengXia Li

    PMID: 28968730

    DOI: 10.1093/bib/bbx109

    Abstract

    Systematic sequencing of cancer genomes has revealed prevalent heterogeneity, with patients harboring various combinatorial patterns of genetic alteration. In particular, a phenomenon that a group of genes exhibits mutually exclusive patterns has been widespread across cancers, covering...read more

    3
    21

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