Identifying myocardial injuries in "normal-appearing" myocardium in pediatric patients with clinically suspected myocarditis using mapping techniques

PeerJ
Haipeng WangCuiyan Wang

Abstract

Mapping techniques using cardiac magnetic resonance imaging have significantly improved the diagnostic accuracy for myocarditis with focal myocardial injuries. The aim of our study was to determine whether T1 and T2 mapping techniques could identify diffuse myocardial injuries in "normal-appearing" myocardium in pediatric patients with clinically suspected myocarditis and to evaluate the associations between diffuse myocardial injuries and cardiac function parameters. Forty-six subjects were included in this study: 20 acute myocarditis patients, 11 subacute/chronic myocarditis patients and 15 control children. T2 values, native T1 values and the extracellular volume (ECV) of "normal-appearing" myocardium were compared among the three groups of patients. Associations between diffuse myocardial injuries and cardiac function parameters were also evaluated. The ECV of "normal-appearing" myocardium was significantly higher in the subacute/chronic myocarditis group than in the control group (30.1 ± 0.9 vs 27.0 ± 0.6, P =0.004). No significant differences in T1 and T2 values between the acute myocarditis and control groups were found. In the subacute/chronic myocarditis group, a significant association between ECV and left ventricle e...Continue Reading

References

Oct 19, 2006·JAMA : the Journal of the American Medical Association·Jeffrey A TowbinSteven E Lipshultz
Apr 10, 2009·JACC. Cardiovascular Imaging·Anja ZagrosekJeanette Schulz-Menger
Apr 10, 2009·The New England Journal of Medicine·Leslie T Cooper
Apr 25, 2009·Journal of the American College of Cardiology·Matthias G FriedrichUNKNOWN International Consensus Group on Cardiovascular Magnetic Resonance in Myocarditis
Jun 24, 2009·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Emanuela Valsangiacomo BuechelChristian J Kellenberger
Jan 30, 2010·Progress in Cardiovascular Diseases·Lori A Blauwet, Leslie T Cooper
Apr 24, 2010·Current Opinion in Pediatrics·Marla C LevineStephen J Teach
Dec 22, 2011·Lancet·Sandeep SagarLeslie T Cooper
Mar 1, 2012·Journal of the American College of Cardiology·Ingrid KindermannMichael Böhm
Mar 24, 2012·Heart·Chantal ElammLeslie T Cooper
Jul 5, 2013·European Heart Journal·Alida L P CaforioUNKNOWN European Society of Cardiology Working Group on Myocardial and Pericardial Diseases
Mar 13, 2014·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Jeremy R BurtDavid A Bluemke
Jun 10, 2014·Radiology·Julian A LuetkensClaas P Naehle
Jul 16, 2014·The International Journal of Cardiovascular Imaging·Sung Ho HwangByoung Wook Choi
Oct 14, 2014·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Scott A HamlinArthur E Stillman
Oct 31, 2014·European Heart Journal Cardiovascular Imaging·Leah M IlesAndrew J Taylor
May 1, 2015·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Nadine Kawel-BoehmDavid A Bluemke
Jul 16, 2015·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Ingo EitelH Thiele
Sep 1, 2015·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Francesca SanguinetiJérôme Garot
Apr 16, 2016·Journal of the American College of Cardiology·Philipp LurzMatthias Gutberlet
Jul 9, 2016·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Ulf K RadunskiKai Muellerleile
Jul 21, 2016·Journal of the American Heart Association·Julian A LuetkensDaniel K Thomas
Nov 26, 2016·Journal of the American College of Cardiology·Stephane HeymansLeslie T Cooper
Dec 3, 2016·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Philip HaafSven Plein
Dec 14, 2018·Journal of the American College of Cardiology·Vanessa M FerreiraMatthias G Friedrich

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsy
biopsies

Software Mentioned

Statistical Package for the Social Sciences ( SPSS
SPSS
Empower Stats

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Human Pathology
C Weinstein, J J Fenoglio
The New England Journal of Medicine
John R Kapoor
Nederlands tijdschrift voor geneeskunde
C A VAN HEES
Belgisch tijdschrift voor geneeskunde
© 2021 Meta ULC. All rights reserved