Identifying Natural Subgroups of Migraine Based on Comorbidity and Concomitant Condition Profiles: Results of the Chronic Migraine Epidemiology and Outcomes (CaMEO) Study

Headache
Richard B LiptonPeter J Goadsby

Abstract

To identify natural subgroups of people with migraine based on profiles of comorbidities and concomitant conditions, hereafter referred to as comorbidities. Migraine is a heterogeneous disease. Identifying natural subgroups (endophenotypes) may facilitate biological and genetic characterization and the development of personalized treatment. The Chronic Migraine Epidemiology and Outcomes Study is a prospective web-based survey study designed to characterize the course of migraine and related comorbidities in a systematic US sample of people with migraine. Respondents were asked if they ever had a specific comorbidity and, if present, whether the comorbidity was confirmed/diagnosed by a "doctor"; 62 comorbidities were available for analysis. Latent class analysis (LCA) modeling determined the optimal number of classes and a parsimonious set of comorbidities. Of the 12,810 respondents with migraine, 11,837 reported ≥1 comorbidity and were included in this analysis. After statistical analysis and clinical judgment reduced the number of comorbidities, we selected an 8-class model based on 22 comorbidities. Each class had a distinct pattern summarized as follows: Class 1, Most Comorbidities; Class 2, Respiratory/Psychiatric; Class 3,...Continue Reading

References

Nov 20, 2003·Twin Research : the Official Journal of the International Society for Twin Studies·Elles J MulderAarno Palotie
Jun 21, 2007·Headache·Gretchen E TietjenLeah White
Mar 26, 2008·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Lannie LigthartDorret I Boomsma
Apr 25, 2009·Human Genetics·Carla Chia Ming ChenKerrie L Mengersen
May 21, 2009·Human Genetics·Boukje de VriesArn M J M van den Maagdenberg
Sep 15, 2009·Lancet Neurology·Peter J Goadsby
Feb 19, 2010·Journal of Neurology, Neurosurgery, and Psychiatry·D C BuseR B Lipton
Sep 10, 2010·Annals of the Institute of Statistical Mathematics·Nema Dean, Adrian E Raftery
Mar 15, 2011·Cephalalgia : an International Journal of Headache·Markus SchürksTobias Kurth
Sep 26, 2012·The Journal of Headache and Pain·Sait AshinaDawn C Buse
Nov 8, 2012·Journal of Neurology·Dawn C BuseRichard B Lipton
May 15, 2013·Cephalalgia : an International Journal of Headache·Else EisingArn M J M van den Maagdenberg
Jun 26, 2013·Nature Genetics·Verneri AnttilaAarno Palotie
Dec 18, 2013·The Journal of Headache and Pain·Jasem Y Al-HashelPeter J Goadsby
Jul 26, 2014·Current Cardiology Reports·Simona Sacco, Tobias Kurth
Oct 12, 2014·Cephalalgia : an International Journal of Headache·Aubrey Manack AdamsRichard B Lipton
Oct 18, 2014·Cephalalgia : an International Journal of Headache·Hans-Christoph DienerDagny Holle
Dec 17, 2014·Lancet Neurology·Michel D FerrariArn M J M van den Maagdenberg
Oct 28, 2015·Cephalalgia : an International Journal of Headache·Anne Francke ChristensenJes Olesen
Mar 12, 2016·Current Opinion in Neurology·Dale R Nyholt, Arn M J M van den Maagdenberg
May 15, 2016·Cephalalgia : an International Journal of Headache·Arn Mjm van den Maagdenberg
Jun 21, 2016·Nature Genetics·Padhraig GormleyAarno Palotie
Dec 30, 2016·International Journal of Behavioral Medicine·Lilian N DindoChadi A Calarge
Jan 7, 2017·Cephalalgia : an International Journal of Headache·Zachary F GerringDale R Nyholt
Mar 8, 2017·The Clinical Respiratory Journal·Yi-Hao PengWen-Chao Ho
Mar 9, 2017·Headache·Heidi G Sutherland, Lyn R Griffiths
Dec 13, 2017·Lancet Neurology·Andrew Charles
Feb 2, 2018·BMJ : British Medical Journal·Kasper AdelborgHenrik Toft Sørensen

❮ Previous
Next ❯

Citations

Nov 20, 2018·Expert Opinion on Therapeutic Targets·Innocenzo RaineroElisa Rubino
Feb 15, 2020·Expert Opinion on Therapeutic Targets·Innocenzo RaineroElisa Rubino
May 28, 2019·Cephalalgia : an International Journal of Headache·Marcela Mendes BragattoLidiane Lima Florencio
Jan 4, 2020·The Journal of Headache and Pain·Álvaro Planchuelo-GómezRodrigo de Luis-García
Mar 19, 2019·Current Opinion in Neurology·Irene de BoerGisela M Terwindt
Feb 20, 2020·Scientific Reports·Yohannes W WoldeamanuelRobert P Cowan
Aug 11, 2019·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Mariana Tedeschi BenattoDébora Bevilaqua-Grossi
Oct 12, 2020·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Álvaro Planchuelo-GómezRodrigo de Luis-García
Oct 6, 2020·Annals of Neurology·Andrea M HarriottCenk Ayata
Nov 10, 2020·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Domingo Palacios-CeñaNapoleon Perez-Farinos
Feb 10, 2021·Clinical Biomechanics·Lidiane Lima FlorencioDébora Bevilaqua-Grossi

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.