Identifying occupational carcinogens: an update from the IARC Monographs

Occupational and Environmental Medicine
Dana LoomisKurt Straif

Abstract

The recognition of occupational carcinogens is important for primary prevention, compensation and surveillance of exposed workers, as well as identifying causes of cancer in the general population. This study updates previously published lists of known occupational carcinogens while providing additional information on cancer type, exposure scenarios and routes, and discussing trends in the identification of carcinogens over time. Data were extracted from International Agency for Research on Cancer (IARC) Monographs covering the years 1971-2017, using specific criteria to ensure occupational relevance and provide high confidence in the causality of observed exposure-disease associations. Selected agents were substances, mixtures or types of radiation classified in IARC Group 1 with 'sufficient evidence of carcinogenicity' in humans from studies of exposed workers and evidence of occupational exposure documented in the pertinent monograph. The number of known occupational carcinogens has increased over time: 47 agents were identified as known occupational carcinogens in 2017 compared with 28 in 2004. These estimates are conservative and likely underestimate the number of carcinogenic agents present in workplaces. Exposure to thes...Continue Reading

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Jul 19, 2018·Occupational and Environmental Medicine·Aaron Blair, Lin Fritschi
Aug 6, 2019·American Journal of Industrial Medicine·Mohamed KhalisBarbara Charbotel
May 31, 2019·Journal of the National Cancer Institute·Elizabeth M WardKathleen A Cronin
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