Identifying Pathophysiological Mechanisms in Heart Failure With Reduced Versus Preserved Ejection Fraction

Journal of the American College of Cardiology
Jasper TrompAdriaan A Voors

Abstract

Information on the pathophysiological differences between heart failure with reduced ejection fraction (HFrEF) versus heart failure with preserved ejection fraction (HFpEF) is needed OBJECTIVES: The purpose of this study was to establish biological pathways specifically related to HFrEF and HFpEF. The authors performed a network analysis to identify unique biomarker correlations in HFrEF and HFpEF using 92 biomarkers from different pathophysiological domains in a cohort of 1,544 heart failure (HF) patients. Data were independently validated in 804 patients with HF. Networks were enriched with existing knowledge on protein-protein interactions and translated into biological pathways uniquely related to HFrEF, HF with a midrange ejection fraction, and HFpEF. In the index cohort (mean age 74 years; 34% female), 718 (47%) patients had HFrEF (left ventricular ejection fraction [LVEF] <40%) and 431 (27%) patients had HFpEF (LVEF ≥50%). A total of 8 (12%) correlations were unique for HFrEF and 6 (9%) were unique to HFpEF. Central proteins in HFrEF were N-terminal B-type natriuretic peptide, growth differentiation factor-15, interleukin-1 receptor type 1, and activating transcription factor 2, while central proteins in HFpEF were integ...Continue Reading

Associated Clinical Trials

Citations

Jan 5, 2019·European Heart Journal·Thomas M GorterAdriaan A Voors
Feb 20, 2019·European Heart Journal·John G F ClelandPiotr Ponikowski
Jun 11, 2019·European Heart Journal·Nicholas Finer
Jun 7, 2019·Circulation·Shannon M DunlayUNKNOWN American Heart Association Heart Failure and Transplantation Committee of the Council on Clinical Cardiology; Council on Car
Dec 7, 2019·European Journal of Heart Failure·Nils BomerPeter van der Meer
Oct 24, 2019·The New England Journal of Medicine·Christopher M O'Connor, Christopher deFilippi
Dec 5, 2019·European Heart Journal·Carolyn S P LamAdriaan A Voors
Jan 23, 2020·Heart Failure Reviews·Wolfgang KruegerMaciej Henneberg
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Jul 2, 2020·Database : the Journal of Biological Databases and Curation·Lan YangBairong Shen
Sep 10, 2019·Aging·Jiahao DuanChun Yang
Nov 30, 2019·European Journal of Heart Failure·Eileen O'Meara, Bruce G Allen
Jun 7, 2019·Journal of Clinical Medicine·Marijana TadicMaurizio Galderisi
Nov 22, 2019·Frontiers in Physiology·Domenico D'AmarioFilippo Crea
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