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Identifying positive selection candidate loci for high-altitude adaptation in Andean populations

Human Genomics

Dec 30, 2009

Abigail W BighamM Shriver

Abstract

High-altitude environments (>2,500 m) provide scientists with a natural laboratory to study the physiological and genetic effects of low ambient oxygen tension on human populations. One approach to understanding how life at high altitude has affected human metabolism is to survey genome...read more

Mentioned in this Paper

Metabolic Process, Cellular
Genome-Wide Association Study
Hypoxia-Inducible Factor Pathway
Study
Biochemical Pathway
Genome
Genes
Candidate Disease Gene
Oxygen Measurement, Partial Pressure, Arterial
Response to Hypoxia
121
Paper Details
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American Journal of Human Biology : the Official Journal of the Human Biology Council

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American Journal of Human Biology : the Official Journal of the Human Biology CouncilJanuary 26, 2013
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Identifying positive selection candidate loci for high-altitude adaptation in Andean populations

Human Genomics

Dec 30, 2009

Abigail W BighamM Shriver

PMID: 20038496

DOI: 10.1186/1479-7364-4-2-79

Abstract

High-altitude environments (>2,500 m) provide scientists with a natural laboratory to study the physiological and genetic effects of low ambient oxygen tension on human populations. One approach to understanding how life at high altitude has affected human metabolism is to survey genome...read more

Mentioned in this Paper

Metabolic Process, Cellular
Genome-Wide Association Study
Hypoxia-Inducible Factor Pathway
Study
Biochemical Pathway
Genome
Genes
Candidate Disease Gene
Oxygen Measurement, Partial Pressure, Arterial
Response to Hypoxia
121

Similar Papers Found In These Feeds

Genome Dynamics and Adaptation

Genome-scale tools are revolutionizing studies of evolution by providing complete determination of the genetic basis of adaptation. Discover the latest research on Genome Dynamics and Adaptation here.

Evolution of Gene Regulation (Keystone)

The evolution from single-celled to multicellular organisms required precise control of genes and gave cells the ability to be programmed for specific functions. Discover the latest research on the evolution of gene regulation and gene regulation in Drosophila in this feed.

Related Papers

American Journal of Human Biology : the Official Journal of the Human Biology Council

Andean and Tibetan patterns of adaptation to high altitude

American Journal of Human Biology : the Official Journal of the Human Biology CouncilJanuary 26, 2013
Abigail W BighamM Shriver
Paper Details
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  • Citations
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