Identifying potential moderators for response to treatment in low back pain: A systematic review

Physiotherapy
Tara GurungMartin Underwood

Abstract

Identifying which patients with non-specific low back pain are likely to gain the greatest benefit from different treatments is an important research priority. Few studies are large enough to produce data on sub-group effects from different treatments. Data from existing large studies may help identify potential moderators to use in future individual patient data meta-analyses. To systematically review papers of therapist delivered interventions for low back pain to identify potential moderators to inform an individual patient data meta-analysis. We searched MEDLINE, EMBASE, Web of Science and Citation Index and Cochrane Register of Controlled Trials (CENTRALhttp://www.cochrane.org/editorial-and-publishing-policy-resource/cochrane-central-register-controlled-trials-central) for relevant papers. We screened for randomised controlled trials with ≥500 or more participants, and cohort studies of ≥1000 or more participants. We examined all publications related to these studies for any reported moderator analyses. Two reviewers independently did risk of bias assessment of main results and quality assessment of any moderator analyses. We included four randomised trials (n=7208). Potential moderators with strong evidence (p<0.05) in on...Continue Reading

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Citations

Oct 22, 2016·The Journal of Pain : Official Journal of the American Pain Society·Jason M BeneciukNadine E Foster
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Jun 21, 2021·Journal of Physiotherapy·Jill A Hayden, Richard D Riley

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