Identifying potential serum biomarkers of breast cancer through targeted free fatty acid profiles screening based on a GC-MS platform.

Biomedical Chromatography : BMC
Binbin TanLi Fu

Abstract

Recent advances suggest that abnormal fatty acid metabolism highly correlates with breast cancer, which provide clues to discover potential biomarkers of breast cancer. This study aims to identify serum free fatty acid (FFA) metabolic profiles and screen potential biomarkers for breast cancer diagnosis. Gas chromatography-mass spectrometry and our in-house fatty acid methyl ester standard substances library were combined to accurately identify FFA profiles in serum samples of breast cancer patients and breast adenosis patients (as controls). Potential biomarkers were screened by applying statistical analysis. A total of 18 FFAs were accurately identified in serum sample. Two groups of patients were correctly discriminated by the orthogonal partial least squares-discriminant analysis model based on FFA profiles. Seven FFA levels were significantly higher in serum from breast cancer patients than that in controls, and exhibited positive correlation with malignant degrees of disease. Furthermore, five candidates (palmitic acid, oleic acid, cis-8,11,14-eicosatrienoic acid, docosanoic acid and the ratio of oleic acid to stearic acid) were selected as potential serum biomarkers for differential diagnosis of breast cancer. Our study w...Continue Reading

References

Jun 18, 2005·Journal of Lipid Research·Alan M Kleinfeld, Clifford Okada
Jul 20, 2006·Nature Chemical Biology·Kazuya Kikuchi, Hideaki Kakeya
Dec 18, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Mitch Dowsett, Anita K Dunbier
Sep 18, 2010·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Liyan LiuChanghao Sun
Oct 21, 2010·Cancer Research·Vincent M AsiagoDaniel Raftery
Mar 8, 2011·Cell·Douglas Hanahan, Robert A Weinberg
Aug 25, 2011·Biomarkers in Medicine·Yasuyuki KondoMasaru Yoshida
Feb 2, 2012·International Journal of Breast Cancer·Andrew A Davis, Virginia G Kaklamani
Sep 25, 2012·Nature·UNKNOWN Cancer Genome Atlas Network
Nov 16, 2012·Nature·Jeremy K NicholsonJohn C Lindon
Dec 5, 2012·Breast Cancer Research and Treatment·Ashley M HolderFunda Meric-Bernstam
Jan 3, 2013·International Journal of Cancer. Journal International Du Cancer·Neill PataniMitch Dowsett
May 17, 2013·Journal of Proteome Research·Binbin TanWei Jia
Jun 25, 2013·Cell Metabolism·Erin CurrieRobert V Farese
Oct 2, 2013·Proceedings of the National Academy of Sciences of the United States of America·Jiang-Han WangSai-Juan Chen
Jun 28, 2014·The Oncologist·Maria Vittoria DieciValentina Guarneri
Oct 30, 2015·CA: a Cancer Journal for Clinicians·Carol E DeSantisAhmedin Jemal
Dec 15, 2015·Journal of the National Comprehensive Cancer Network : JNCCN·William J GradisharRashmi Kumar
Dec 18, 2015·World Journal of Clinical Oncology·Budhi S YadavSwaty Jhamb
Jun 28, 2016·Oncology Letters·Yin-Hsun FengChao-Liang Wu
Oct 25, 2016·Nature Reviews. Cancer·Florian Röhrig, Almut Schulze
Feb 15, 2017·BBA Clinical·Kiven Erique Lukong
Sep 19, 2017·Expert Opinion on Therapeutic Targets·Javier A Menendez, Ruth Lupu
Dec 9, 2017·Cell Research·Paolo Ettore PorporatoLorenzo Galluzzi
Dec 9, 2017·Journal of Cellular Physiology·Seyed Hamed JafariMojtaba Kianmehr
May 19, 2018·Cancer Treatment Reviews·Amelia McCartneyAngelo Di Leo
Mar 5, 2019·Metabolomics : Official Journal of the Metabolomic Society·Biswapriya B MisraMichael Olivier

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Citations

Oct 1, 2020·Cancers·Jiawei LiDong-Xu Liu
Apr 2, 2021·Expert Review of Proteomics·Md Mahamodun NabiMitsutoshi Setou
Jun 3, 2021·International Journal of Molecular Sciences·Marcela Valko-RokytovskáZuzana Kostecká

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