Identifying potential survival strategies of HIV-1 through virus-host protein interaction networks.

BMC Systems Biology
David van DijkPeter Ma Sloot

Abstract

The National Institute of Allergy and Infectious Diseases has launched the HIV-1 Human Protein Interaction Database in an effort to catalogue all published interactions between HIV-1 and human proteins. In order to systematically investigate these interactions functionally and dynamically, we have constructed an HIV-1 human protein interaction network. This network was analyzed for important proteins and processes that are specific for the HIV life-cycle. In order to expose viral strategies, network motif analysis was carried out showing reoccurring patterns in virus-host dynamics. Our analyses show that human proteins interacting with HIV form a densely connected and central sub-network within the total human protein interaction network. The evaluation of this sub-network for connectivity and centrality resulted in a set of proteins essential for the HIV life-cycle. Remarkably, we were able to associate proteins involved in RNA polymerase II transcription with hubs and proteasome formation with bottlenecks. Inferred network motifs show significant over-representation of positive and negative feedback patterns between virus and host. Strikingly, such patterns have never been reported in combined virus-host systems. HIV infectio...Continue Reading

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Citations

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Jul 7, 2020·Frontiers in Microbiology·Sergey IvanovOlga Tarasova

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Datasets Mentioned

BETA
NP444284.1
NP055629.1
NP002805.1
NP054721.1

Methods Mentioned

BETA
environmental stress

Software Mentioned

Cytoscape
MAVisto
FANMOD
Prolog
IGraph
DAVID
R
Mfinder
Prolog script

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