Identifying preclinical vascular dementia in symptomatic small vessel disease using MRI.

NeuroImage. Clinical
Christian LambertHugh S Markus

Abstract

Sporadic cerebral small vessel disease is an important cause of vascular dementia, a syndrome of cognitive impairment together with vascular brain damage. At post-mortem pure vascular dementia is rare, with evidence of co-existing Alzheimer's disease pathology in 95% of cases. This work used MRI to characterize structural abnormalities during the preclinical phase of vascular dementia in symptomatic small vessel disease. 121 subjects were recruited into the St George's Cognition and Neuroimaging in Stroke study and followed up longitudinally for five years. Over this period 22 individuals converted to dementia. Using voxel-based morphometry, we found structural abnormalities present at baseline in those with preclinical dementia, with reduced grey matter density in the left striatum and hippocampus, and more white matter hyperintensities in the frontal white-matter. The lacunar data revealed that some of these abnormalities may be due to lesions within the striatum and centrum semiovale. Using support vector machines, future dementia could be best predicted using hippocampal and striatal Jacobian determinant data, achieving a balanced classification accuracy of 73%. Using cluster ward linkage we identified four anatomical subty...Continue Reading

Citations

Sep 13, 2019·Stroke; a Journal of Cerebral Circulation·Owen A WilliamsRebecca A Charlton
Jan 7, 2020·JAMA Neurology·Jack F V HuntBarbara B Bendlin
Feb 20, 2020·Magnetic Resonance in Medical Sciences : MRMS : an Official Journal of Japan Society of Magnetic Resonance in Medicine·Masami GotoHiroyuki Daida
Mar 15, 2019·Evidence-based Complementary and Alternative Medicine : ECAM·Kui HuangYunpeng Cao
Jul 12, 2020·Journal of Neurology, Neurosurgery, and Psychiatry·Jonathan TayHugh S Markus
Jan 13, 2021·Neural Regeneration Research·Morgan J SchaefferPhilip A Barber
Feb 10, 2021·Journal of Neurology, Neurosurgery, and Psychiatry·Marco EgleHugh S Markus

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