Identifying predictive behavioral markers: A demonstration using automatically reinforced self-injurious behavior.

Journal of Applied Behavior Analysis
Louis P HagopianGayane Yenokyan

Abstract

Predictive biomarkers (PBioMs) are objective biological measures that predict response to medical treatments for diseases. The current study translates methods used in the field of precision medicine to identify PBioMs to identify parallel predictive behavioral markers (PBMs), defined as objective behavioral measures that predict response to treatment. We demonstrate the utility of this approach by examining the accuracy of two PBMs for automatically reinforced self-injurious behavior (ASIB). Results of the analysis indicated both functioned as good to excellent PBMs. We discuss the compatibility of this approach with applied behavior analysis, describe methods to identify additional PBMs, and posit that variables related to the mechanisms of problem behavior and putative mechanism of treatment action hold the most promise as potential PBMs. We discuss how this technology could guide individualized treatment selection, inform our understanding of problem behavior and mechanisms of treatment action, and help determine the conditional effectiveness of clinical procedures.

References

Jan 1, 1994·Journal of Applied Behavior Analysis·B A IwataR G Miltenberger
Jul 1, 1997·Journal of Applied Behavior Analysis·L P HagopianD P Wacker
Oct 3, 1998·Journal of Applied Behavior Analysis·D M RichmanS D Casey
Apr 14, 1999·Journal of Applied Behavior Analysis·D E KuhnA E Wilke
Oct 8, 1999·Journal of Applied Behavior Analysis·D M RichmanM Andelman
Jan 21, 2000·Journal of Applied Behavior Analysis·T R VollmerD Daniel
Jul 8, 2000·Journal of Applied Behavior Analysis·N Miller, A Neuringer
Apr 25, 2001·Journal of Applied Behavior Analysis·T S Critchfield, S H Kollins
May 26, 2001·BMJ : British Medical Journal·I J Higginson, A J Carr
Sep 11, 2002·Behavior Modification·Lee KernChristina Elliot
Nov 9, 2004·Journal of Applied Behavior Analysis·Jennifer M AsmusDavid P Wacker
Apr 1, 1968·Journal of Applied Behavior Analysis·D M BaerT R Risley
Jan 1, 1995·Journal of Applied Behavior Analysis·J S Lalli, F C Mace
May 14, 2009·Journal of Clinical Child and Adolescent Psychology : the Official Journal for the Society of Clinical Child and Adolescent Psychology, American Psychological Association, Division 53·Sigmund EldevikScott Cross
Aug 25, 2011·Nature Reviews. Clinical Oncology·Nicholas B La Thangue, David J Kerr
Sep 24, 2011·Journal of Applied Behavior Analysis·Jeanne M DonaldsonKerri P Berard
Nov 19, 2011·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Stuart A Scott
Jun 1, 2012·Behavior Analysis in Practice·Derek D Reed, Brent A Kaplan
Mar 8, 2013·Nature Medicine·Alla Katsnelson
Oct 12, 2013·Journal of Applied Behavior Analysis·Jennifer N FritzSarah E Bloom
Oct 12, 2013·Journal of Applied Behavior Analysis·Henry S RoaneKelly J Bouxsein
Dec 17, 2014·Personalized Medicine·Ross A Okimoto, Trever G Bivona
Aug 1, 2015·Journal of Applied Behavior Analysis·Louis P HagopianJennifer R Zarcone
Oct 21, 2015·Journal of Applied Behavior Analysis·Brian D GreerJamie K Jones
May 14, 2016·Journal of Applied Behavior Analysis·Wayne W FisherTodd M Owen
May 14, 2016·Journal of Applied Behavior Analysis·Joshua JesselMahshid Ghaemmaghami
Jul 28, 2016·Journal of Applied Behavior Analysis·Mahshid GhaemmaghamiJoshua Jessel
Dec 30, 2016·Journal of Applied Behavior Analysis·Louis P HagopianAlexander R Arevalo
Mar 18, 2017·Journal of Applied Behavior Analysis·Jessica D SlatonKatherine J Raftery
Oct 14, 2017·Journal of Intellectual Disability Research : JIDR·L P Hagopian, M A Frank-Crawford

❮ Previous
Next ❯

Citations

Jun 22, 2019·Autism Research : Official Journal of the International Society for Autism Research·Matthew S GoodwinMatthew Siegel
Jun 25, 2020·Journal of Applied Behavior Analysis·John Michael FalligantGriffin W Rooker
Jul 22, 2020·Journal of Applied Behavior Analysis·John Michael Falligant, Louis P Hagopian
Jul 24, 2020·Journal of Applied Behavior Analysis·Tara A FahmieSandy Jin
Apr 10, 2019·Behavior Modification·Maithri Sivaraman, John T Rapp
Jun 27, 2020·Journal of Applied Behavior Analysis·Louis P HagopianGriffin W Rooker
Jul 11, 2020·Perspectives on Behavior Science·John Michael FalligantGriffin W Rooker
Nov 27, 2019·Journal of Applied Behavior Analysis·Griffin W RookerKatharine S Finney
Aug 6, 2019·Journal of Applied Behavior Analysis·Kara L WunderlichEliana Pizarro
Jan 7, 2022·Journal of Applied Behavior Analysis·Kara L WunderlichLauren Best

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.