Identifying predictive factors for vertebral collapse fractures in multiple myeloma patients.

The Spine Journal : Official Journal of the North American Spine Society
Hester ZijlstraDiederik H R Kempen

Abstract

Vertebral compression fractures (VCFs) are a common complication for patients with multiple myeloma. These fractures are associated with significant morbidity and mortality due to severe back pain, spinal instability, increased risk of new fractures, neurologic dysfunction, and other physical symptoms. To identify risk factors associated with the development of VCFs which may help to predict them in future patients. A retrospective multicenter cohort study. Patients with multiple myeloma diagnosed between 2012 and 2018 and appropriate baseline- and follow-up imaging studies (>6 months after diagnosis) were included. Individual odds ratios for each of the fifteen potential risk factors including patient factors and radiographical characteristics. Relevant clinical baseline data were extracted from the patient charts. Computed tomography (CT) scans were used to score all radiographic variables. VCFs were graded following the Genant grading system. General Linear Mixed Models were used to analyze risk factors associated with vertebral fractures. A total of 143 patients with 1,605 eligible vertebrae were included in the study with a mean follow-up time of 25 months. Mean age at diagnosis was 65 years and 39% were female. Among 1,60...Continue Reading

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