Identifying SARS-CoV-2 Entry Inhibitors through Drug Repurposing Screens of SARS-S and MERS-S Pseudotyped Particles

ACS Pharmacology & Translational Science
Catherine Z ChenGary R Whittaker

Abstract

While vaccine development will hopefully quell the global pandemic of COVID-19 caused by SARS-CoV-2, small molecule drugs that can effectively control SARS-CoV-2 infection are urgently needed. Here, inhibitors of spike (S) mediated cell entry were identified in a high throughput screen of an approved drugs library with SARS-S and MERS-S pseudotyped particle entry assays. We discovered six compounds (cepharanthine, abemaciclib, osimertinib, trimipramine, colforsin, and ingenol) to be broad spectrum inhibitors for spike-mediated entry. This work could contribute to the development of effective treatments against the initial stage of viral infection and provide mechanistic information that might aid the design of new drug combinations for clinical trials for COVID-19 patients.

Citations

Jan 14, 2021·The Biochemical Journal·George M Burslem
Jan 13, 2021·Nature Structural & Molecular Biology·Tianshu XiaoBing Chen
Feb 25, 2021·Nature Biotechnology·Ruili HuangWei Zheng
Feb 24, 2021·Trends in Microbiology·Lucia Gutierrez-ChamorroEster Ballana
Jun 4, 2021·Journal of Medicinal Chemistry·Thanigaimalai Pillaiyar, Stefan Laufer
Dec 22, 2020·ACS Infectious Diseases·Kirill GorshkovWei Zheng
Jun 13, 2021·Signal Transduction and Targeted Therapy·Qianqian ZhangFei Yu

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BETA
electron microscopy
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