Identifying Shared Brain Networks in Individuals by Decoupling Functional and Anatomical Variability.

Cerebral Cortex
Georg LangsHesheng Liu

Abstract

The connectivity architecture of the human brain varies across individuals. Mapping functional anatomy at the individual level is challenging, but critical for basic neuroscience research and clinical intervention. Using resting-state functional connectivity, we parcellated functional systems in an "embedding space" based on functional characteristics common across the population, while simultaneously accounting for individual variability in the cortical distribution of functional units. The functional connectivity patterns observed in resting-state data were mapped in the embedding space and the maps were aligned across individuals. A clustering algorithm was performed on the aligned embedding maps and the resulting clusters were transformed back to the unique anatomical space of each individual. This novel approach identified functional systems that were reproducible within subjects, but were distributed across different anatomical locations in different subjects. Using this approach for intersubject alignment improved the predictability of individual differences in language laterality when compared with anatomical alignment alone. Our results further revealed that the strength of association between function and macroanatomy...Continue Reading

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Citations

Mar 16, 2017·Proceedings of the National Academy of Sciences of the United States of America·Aristeidis SotirasChristos Davatzikos
Apr 18, 2018·PLoS Computational Biology·J Swaroop GuntupalliJames V Haxby
Dec 10, 2019·Cerebral Cortex·Meizhen HanJia-Hong Gao
Apr 2, 2017·Scientific Reports·Richard F BetzelDanielle S Bassett
Oct 9, 2020·Nature Communications·Yuxiang YanHesheng Liu
Aug 4, 2019·NeuroImage. Clinical·Şeyma BayrakSmadar Ovadia-Caro
Jul 1, 2021·Network Neuroscience·Giulia LioiNicolas Farrugia
Jul 15, 2021·Proceedings of the National Academy of Sciences of the United States of America·Hao-Ming DongAvram J Holmes
Sep 17, 2021·Communications Biology·Oualid BenkarimBoris C Bernhardt

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