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Identifying signatures of natural selection in Tibetan and Andean populations using dense genome scan data

PLoS Genetics

Sep 15, 2010

Abigail BighamMark D Shriver

Abstract

High-altitude hypoxia (reduced inspired oxygen tension due to decreased barometric pressure) exerts severe physiological stress on the human body. Two high-altitude regions where humans have lived for millennia are the Andean Altiplano and the Tibetan Plateau. Populations living in thes...read more

Mentioned in this Paper

Genetic Drift
Metabolic Process, Cellular
Study
Biochemical Pathway
EGLN1
Patterns
Exertion
Lactase Persistence
Molecular Helix
IL1A gene
13
11
365
1
3
1
Paper Details
References
  • References65
  • Citations191
12345...
  • References65
  • Citations191
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Identifying signatures of natural selection in Tibetan and Andean populations using dense genome scan data

PLoS Genetics

Sep 15, 2010

Abigail BighamMark D Shriver

PMID: 20838600

DOI: 10.1371/journal.pgen.1001116

Abstract

High-altitude hypoxia (reduced inspired oxygen tension due to decreased barometric pressure) exerts severe physiological stress on the human body. Two high-altitude regions where humans have lived for millennia are the Andean Altiplano and the Tibetan Plateau. Populations living in thes...read more

Mentioned in this Paper

Genetic Drift
Metabolic Process, Cellular
Study
Biochemical Pathway
EGLN1
Patterns
Exertion
Lactase Persistence
Molecular Helix
IL1A gene
13
11
365
1
3
1

Similar Papers Found In These Feeds

Chemokines & Chemokine Receptors

Chemokines are a subset of cytokines which induce chemotaxis in cells expressing chemokine receptors. Chemokines can be broadly categorized into two functional subgroups, homeostatic (basal expression in lymphoid tissues for surveillance purposes) or inflammatory (released during injury to recruit immune effector cells). Chemokine receptors are G-protein coupled receptors which, upon chemokine binding, induce calcium influx into the cell. Find the latest research on chemokines and chemokine receptors here.

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Discover the latest genomics research in this collection of the top open access genomics journals.

Related Papers

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Genetic evidence for high-altitude adaptation in Tibet

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The genetic architecture of adaptations to high altitude in Ethiopia

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Paper Details
References
  • References65
  • Citations191
12345...
  • References65
  • Citations191
12345...
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