Identifying subtypes of mild cognitive impairment from healthy aging based on multiple cortical features combined with volumetric measurements of the hippocampal subfields

Quantitative Imaging in Medicine and Surgery
Shengwen GuoAlzheimer’s Disease Neuroimaging Initiative

Abstract

Mild cognitive impairment (MCI) is subtle cognitive decline with an estimated 10-15% yearly conversion rate toward Alzheimer's disease (AD). It remains unexplored in brain cortical association areas in different lobes and its changes with progression and conversion of MCI. Brain structural magnetic resonance (MR) images were collected from 102 stable MCI (sMCI) patients. One hundred eleven were converted MCI (cMCI) patients, and 109 were normal control (NC). The cortical surface features and volumes of subcortical hippocampal subfields were calculated using the FreeSurfer software, followed by an analysis of variance (ANOVA) model, to reveal the differences between the NC-sMCI, NC-cMCI, and sMCI-cMCI groups. Afterward, the support vector machine-recursive feature elimination (SVM-RFE) method was applied to determine the differences between the groups. The experimental results showed that there were progressive degradations in either range or degree of the brain structure from NC to sMCI, and then to cMCI. The SVM classifier obtained accuracies with 64.62%, 78.96%, and 70.33% in the sMCI-NC, cMCI-NC, and cMCI-sMCI groups, respectively, using the volumes of hippocampal subfields independently. The combination of the volumes from ...Continue Reading

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