Identifying susceptibility loci for nicotine dependence: 2008 update based on recent genome-wide linkage analyses.

Human Genetics
Ming D Li

Abstract

Tobacco smoking is a severe health hazard worldwide, as nearly one-third of the global adult population smokes tobacco products. This high prevalence highlights the importance of studying the genetic determinants of nicotine dependence (ND). To identify such genetic factors, more than 20 genome-wide linkage studies have been conducted across different populations using a variety of ND assessment approaches, including smoking quantity (SQ), Heaviness of Smoking Index (HSI), Fagerström Test for Nicotine Dependence (FTND), ever-smoking, habitual smoking, or maximum number of cigarettes smoked in a 24-h period. This review provides a critical update on the progress during the years since our last review, published in 2004, in identifying susceptibility loci for ND. Although a significant number of reported genomic regions did not reach the level of "suggestive" or "significant" linkage and failed to be replicated in other independent studies, thirteen regions, located on chromosomes 3-7, 9-11, 17, 20, and 22, have been found to be suggestive or significant in at least two independent samples. Among them, the regions on chromosomes 9 (91.9-136.5 cM), 10, 11, and 17 have received the strongest support. A summary of eight regions that...Continue Reading

References

Sep 17, 1992·The New England Journal of Medicine·D CarmelliR Fabsitz
Apr 28, 1999·Psychological Medicine·K S KendlerC A Prescott
Jul 13, 1999·Archives of General Psychiatry·W R TrueM Tsuang
Dec 22, 1999·Genetic Epidemiology·A W BergenA M Goldstein
Jun 17, 2000·Behavior Genetics·P A MaddenN G Martin
Sep 5, 2002·International Journal of Health Services : Planning, Administration, Evaluation·Eeva Ollila, Meri Koivusalo
Dec 18, 2003·American Journal of Medical Genetics. Part a·Laura Jean BierutTheodore Reich
Feb 21, 2004·BMC Genetics·Andrew W BergenUNKNOWN Framingham Heart Study
Feb 21, 2004·BMC Genetics·Ellen L GoodeUNKNOWN Framingham Heart Study
Feb 21, 2004·BMC Genetics·Ming D LiUNKNOWN Framingham Heart Study
Feb 21, 2004·BMC Genetics·Nancy L SacconeJohn P Rice
Mar 30, 2004·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Patrick F SullivanKenneth S Kendler
Jun 2, 2004·The Pharmacogenomics Journal·J M VinkD I Boomsma
Jun 24, 2004·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Joel GelernterHeping Zhang
Jun 26, 2004·Annual Review of Neuroscience·Raul R GainetdinovMarc G Caron
Feb 19, 2005·Proceedings of the National Academy of Sciences of the United States of America·Amyaouch BradaïaChristian Lüscher
Jun 23, 2005·Behavior Genetics·Jacqueline M VinkDorret I Boomsma
Dec 24, 2005·Behavior Genetics·Jacqueline M VinkDorret I Boomsma
Feb 14, 2006·BMC Medical Genetics·Cindy L Ehlers, Kirk C Wilhelmsen
May 4, 2006·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Gary E SwanNeal Benowitz
Jun 13, 2006·Genes, Brain, and Behavior·Cindy L Ehlers, Kirk C Wilhelmsen
Nov 4, 2006·Biological Psychiatry·Joel GelernterHenry R Kranzler
Dec 16, 2006·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Joke BeutenMing D Li
Jan 17, 2007·The Pharmacogenomics Journal·M K Ho, R F Tyndale
Apr 17, 2007·American Journal of Human Genetics·Scott F SacconePamela A F Madden

❮ Previous
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Citations

Nov 4, 2011·Human Genetics·Wen-Yan CuiMing D Li
Dec 31, 2011·Human Genetics·Eric W KleeStephen C Ekker
Feb 1, 2012·Human Genetics·Allison B Gold, Caryn Lerman
Jan 21, 2011·European Journal of Human Genetics : EJHG·Rossella SoriceDaniela Toniolo
Apr 27, 2010·Nature Genetics·UNKNOWN Tobacco and Genetics Consortium
Apr 27, 2010·Nature Genetics·Jason Z LiuJonathan Marchini
Jun 6, 2009·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Andrew W BergenGary E Swan
Mar 25, 2011·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Adriana LoriJoseph F Cubells
Feb 25, 2009·Nature Reviews. Genetics·Ming D Li, Margit Burmeister
Oct 28, 2009·Proceedings of the National Academy of Sciences of the United States of America·Andrew M PetzoldStephen C Ekker
Oct 7, 2010·Journal of Addictive Diseases·Nestor D KapustaHenriette Walter
Aug 22, 2009·Advances in Neonatal Care : Official Journal of the National Association of Neonatal Nurses·Sharron Forest
Jan 12, 2010·Pharmacogenetics and Genomics·Jennifer A WilkingJerry A Stitzel
Apr 28, 2010·Journal of Health and Social Behavior·Jason D BoardmanFred C Pampel
Jan 15, 2011·Respiratory Research·Deog Kyeom KimUNKNOWN COPD Gene Investigators
Jun 22, 2012·PloS One·Vanessa Argondizo dos SantosKatherine Siminovitch
Jan 26, 2013·PloS One·Firdaus A A Mohamed HoeseinPieter Zanen
Sep 11, 2008·Pharmacogenomics·Sean P David, Marcus R Munafò
Mar 10, 2011·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Eric W KleeStephen C Ekker
Dec 3, 2014·Journal of Psychiatric Research·Xiang Yang ZhangJair C Soares
Feb 9, 2012·Addictive Behaviors·Jinxue WeiXiaohong Ma
Oct 13, 2009·Biological Psychiatry·Shizhong HanBao-Zhu Yang
Jan 31, 2009·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Michele L PergadiaPamela A F Madden
Sep 12, 2008·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Yungang HeGary E Swan
Nov 11, 2008·Annals of the New York Academy of Sciences·Francis Joseph McClernon, Scott Haden Kollins
Nov 15, 2011·Journal of Psychiatric and Mental Health Nursing·C A Karvonen-GutierrezS A Duffy
Mar 30, 2011·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Shizhong HanJoel Gelernter
May 13, 2010·Movement Disorders : Official Journal of the Movement Disorder Society·Giuseppe De PalmaUNKNOWN Geoparkinson Study Group
May 29, 2009·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Gustavo L KortmannClaiton H D Bau
Jun 7, 2008·Biological Psychiatry·Ming D LiRobert C Elston
Jun 9, 2015·Drug and Alcohol Dependence·Xiaorong YangChongqi Jia

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