Abstract
Symptoms guide disease management, and patients frequently report HIV-related symptoms, but HIV symptom patterns reported by patients have not been described in the era of improved antiretroviral treatment. The objectives of our study were to investigate the prevalence and burden of symptoms in people living with HIV and attending an outpatient clinic. The prevalence, burden, and bothersomeness of symptoms reported by patients in routine clinic visits during 2011 were assessed using the 20-item HIV Symptom Index. Principal component analysis was used to identify symptom clusters and relationships between groups using appropriate statistic techniques. Two main clusters were identified. The most prevalent and bothersome symptoms were muscle aches/joint pain, fatigue, and poor sleep. A third of patients had seven or more symptoms, including the most burdensome symptoms. Even with improved antiretroviral drug side-effect profiles, symptom prevalence and burden, independent of HIV viral load and CD4+ T cell count, are high.
References
Jan 1, 1984·Health Education Quarterly·N K Janz, M H Becker
May 1, 1994·Journal of Clinical Epidemiology·C C WhalenC S Landefeld
Mar 1, 1997·ANS. Advances in Nursing Science·E R LenzF Suppe
Jul 9, 1999·Diabetes/metabolism Research and Reviews·A R Mire-SluisA Lernmark
Apr 12, 2001·Journal of Advanced Nursing·M DoddD Taylor
Dec 26, 2001·Journal of Clinical Epidemiology·A C JusticeUNKNOWN Adult AIDS Clinical Trials Unit Outcomes Committee
Dec 1, 2006·The New England Journal of Medicine·UNKNOWN Strategies for Management of Antiretroviral Therapy (SMART) Study GroupC Rappoport
Feb 12, 2008·International Journal of Epidemiology·Mari M KitahataMichael S Saag
Jun 26, 2008·PloS One·Petronela AncutaDana Gabuzda
Feb 3, 2009·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Winson Y CheungCamilla Zimmermann
Aug 6, 2009·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Mirjam-Colette KempfMichael S Saag
May 22, 2010·AIDS and Behavior·E J EdelmanA C Justice
Nov 26, 2010·Annual Review of Medicine·Steven G Deeks
Jan 22, 2011·The Journal of Infectious Diseases·Netanya G SandlerUNKNOWN INSIGHT SMART Study Group
Feb 8, 2011·AIDS·Jarek HarezlakUNKNOWN HIV Neuroimaging Consortium
Mar 8, 2011·The Journal of the Association of Nurses in AIDS Care : JANAC·Caryl GayKathryn A Lee
May 24, 2011·Molecular Pain·Wenwen ZhengShuanglin Hao
Nov 26, 2011·Journal of Pain and Symptom Management·Jessica S MerlinIan Frank
May 10, 2012·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Anupa KamatDana Gabuzda
Jun 27, 2012·Brain, Behavior, and Immunity·Nancy G KlimasMary Ann Fletcher
Mar 9, 2013·AIDS Research and Human Retroviruses·John R KoetheTodd Hulgan
Apr 6, 2013·The Journal of Infectious Diseases·Kristine M ErlandsonThomas B Campbell
Jun 26, 2013·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Michael J MugaveroMelanie A Thompson
Oct 12, 2014·The Journal of the Association of Nurses in AIDS Care : JANAC·Natalie L WilsonMirjam-Colette Kempf
Nov 14, 2014·Journal of the International AIDS Society·Jennifer McGowanFiona Lampe
Nov 14, 2014·Journal of the International AIDS Society·Robert BaranMarisol Martinez
Jan 13, 2015·World Journal of Gastroenterology : WJG·Gian Eugenio TontiniHelmut Neumann
Citations
Aug 18, 2016·The American Journal of Drug and Alcohol Abuse·Mollie A Monnig
Mar 7, 2018·Menopause : the Journal of the North American Menopause Society·Rebecca SchnallNancy Reame
Jul 29, 2018·AIDS and Behavior·Lori A J Scott-SheldonMichael P Carey
Oct 6, 2018·AIDS·Caroline A SabinAlan Winston
Nov 11, 2017·The Journal of the Association of Nurses in AIDS Care : JANAC·Linlin LindayaniNai-Ying Ko
Oct 29, 2018·AIDS and Behavior·Allison R WebelBenigno Rodriguez
Dec 21, 2019·The Journal of the Association of Nurses in AIDS Care : JANAC·Mary Beth MakicPaul F Cook
Mar 26, 2019·The Journal of the Association of Nurses in AIDS Care : JANAC·Rebecca SchnallD Scott Batey
Aug 23, 2019·Journal of Women's Health·Rebecca SchnallNancy Reame
Feb 23, 2020·The Journal of the Association of Nurses in AIDS Care : JANAC·Joan N ChukwurahAllison Webel
Jul 10, 2019·BMC Infectious Diseases·Kelly K O'BrienTammy Yates
Jul 10, 2020·Journal of Advanced Nursing·Nathanial SchreinerAllison Webel
Aug 3, 2017·The Journal of the Association of Nurses in AIDS Care : JANAC·Julie Ann ZunigaAlexandra A García
Jan 23, 2018·AIDS Care·Rebecca SchnallSabina Hirshfield
Apr 10, 2019·AIDS Care·Patricia A CioeChristopher W Kahler
Mar 2, 2019·The Journal of the Association of Nurses in AIDS Care : JANAC·Zheng ZhuAnn Bartley Williams
May 28, 2017·The Journal of the Association of Nurses in AIDS Care : JANAC·Shu FarmerDallas Swendeman
Jul 25, 2019·Revista latino-americana de enfermagem·Aliny Cristini PereiraPriscilla Hortense
Jun 20, 2017·BioMed Research International·Antonio GermanoMassimo E Maffei
Jan 26, 2021·AIDS Care·Feifei HuangJudy Ah-Yune
Dec 19, 2020·International Journal of Environmental Research and Public Health·Shubhadeep RoychoudhuryPetr Slama
Nov 7, 2020·PloS One·Olugbenga Oluseun OluwagbemiCang Hui
Mar 17, 2021·Mayo Clinic Proceedings·Nigel KnoxSteven P Cohen
Apr 30, 2021·Cannabis and Cannabinoid Research·Natalie L WilsonRonald J Ellis
Jun 3, 2021·AIDS Care·Ranveig LangsethVegard Skogen
Jun 29, 2021·Frontiers in Psychology·Maria José Fuster-RuizdeApodacaJeffrey V Lazarus
Jun 8, 2021·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Zheng ZhuBei Wu
Dec 29, 2021·European Journal of Cancer Care·Shuxian LinSiyuan Tang