Identifying the association between interleukin-6 and lichen planus: A meta-analysis

Biomedical Reports
Meng YinSong Lin

Abstract

Numerous studies have examined the association between interleukin-6 and the pathogenesis of lichen planus (LP)/oral LP (OLP) in various populations; however, there is a lack of systematic analysis. The aim of the present study was to assess this association more precisely, thus a meta-analysis was performed. Case-control studies, which were published up to December 2015, were obtained from PubMed, Embase and the China National Knowledge Infrastructure databases. Data were extracted and pooled mean differences (MDs) with 95% confidence intervals (CIs) were calculated. Ultimately, eight studies were included, comprising 299 LP/OLP cases and 231 control subjects. Overall, the pooled MD for IL-6 was 16.24 (95% CI, 9.84-22.64; I(2)=99% for heterogeneity). In the subgroup analysis by ethnicity, a significant increase of the IL-6 expression level was identified among Asian individuals, but not in Caucasian individuals. Thus, IL-6 may be significant in the pathogenesis of LP. However, further studies are required to validate these associations.

References

Oct 1, 1991·Journal of the American Academy of Dermatology·A S Boyd, K H Neldner
Nov 1, 1988·European Journal of Immunology·T HiranoM Feldmann
Feb 1, 1988·International Journal of Oral and Maxillofacial Surgery·A M KilpiP C Reade
Nov 1, 1984·The British Journal of Dermatology·J B MatthewsA J Potts
Jul 21, 1995·Annals of the New York Academy of Sciences·B ToruniowaA Pietrzak
Dec 1, 1994·Oral Surgery, Oral Medicine, and Oral Pathology·T YamamotoT Osaki
Sep 1, 1994·The British Journal of Dermatology·P B SugermanG J Seymour
Jan 1, 1994·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·E E KaragouniA Sklavounou
Jan 1, 1996·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·M HibiT Hirano
Apr 3, 1997·The New England Journal of Medicine·P M RidkerC H Hennekens
Mar 29, 2000·The British Journal of Dermatology·P B SugermanM Bigby
Jun 22, 2002·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Andy SunChun-Pin Chiang
Feb 14, 2004·The Journal of Investigative Dermatology·Marco CarrozzoSergio Gandolfo
Dec 8, 2004·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Gao Man GuJoel Epstein
Jul 23, 2005·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Giovanni LodiKobkan Thongprasom
Oct 17, 2009·International Journal of Dental Hygiene·F Agha-HosseiniM Abdollahi
Feb 26, 2010·Clinical Pharmacology and Therapeutics·N Nishimoto
Oct 7, 2010·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·M R RoopashreeAbhilasha Shukla
Nov 5, 2011·Oral Diseases·L NibaliN Donos
May 16, 2012·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Farzaneh Agha-HosseiniMohammad Abdollahi
Apr 13, 2013·The Journal of Contemporary Dental Practice·Farzaneh Agha-Hosseini, Iraj Mirzaii-Dizgah
May 11, 2013·Archives of Oral Biology·Márcia Rodrigues PayerasFernanda Gonçalves Salum
Jun 18, 2014·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Ayman Abdel-HaqMaria Chomyszyn-Gajewska
Sep 8, 2015·Contemporary Clinical Trials·Rebecca DerSimonian, Nan Laird
Nov 5, 2015·Journal of Clinical and Experimental Dentistry·Sinny GoelSunita Gupta

❮ Previous
Next ❯

Citations

Jul 3, 2019·Medicines·Lisa L ZhaiNicholas K Mollanazar
Jul 3, 2019·Journal of the European Academy of Dermatology and Venereology : JEADV·H Husein-ElAhmedM Steinhoff
Feb 6, 2020·Experimental and Therapeutic Medicine·Xintian CaiNanfang Li
Mar 12, 2021·Clinical Oral Investigations·Svetlana TarasenkoAlexey Unkovskiy

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.