Identifying the changes in gene profiles regulating the amelioration of age-related oxidative damages in kidney tissue of rats by the intervention of adult-onset calorie restriction

Rejuvenation Research
Jie ChenRunsheng Ruan

Abstract

This study was initiated to investigate gene expression profiles that are involved in the molecular mechanisms regulating the amelioration of age-related oxidative damages in male Fischer-344 rats (12 months) through adult-onset calorie restriction (CR) intervention for 6 months. The adult-onset CR was initiated with 10 and 25% restriction for the first and second weeks, respectively, and then maintained at 40% throughout the experiment. The adult-onset CR significantly (p < 0.05) decreased urinary 8-isoprostane and protein carbonyl in kidney for the markers of lipid peroxidation and protein oxidation, respectively, in rats from the CR group when compared with control group. Based on Yu's and Melk's methods, the age-related renal pathological changes in the kidney of rats from CR group were retarded by adult-onset CR. Such changes could result from the decrease of plasminogen activation inhibition-1 and clusterin and the increase of kallikrein mRNA expressions significantly (p < 0.05) in the kidneys of rats from the CR group. They were further confirmed by quantitative RT-PCR. Moreover, inflammatory response pathway was down-regulated significantly (p < 0.05) in rats from the CR group, while fatty acid synthesis, mitochondrial ...Continue Reading

References

Jun 1, 1975·Journal of the National Cancer Institute·B SassG J Kelloff
Oct 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·L D YoungmanB N Ames
Nov 1, 1985·Journal of Gerontology·H MaedaB P Yu
Jul 1, 1995·The International Journal of Biochemistry & Cell Biology·M E Rosenberg, J Silkensen
Jul 5, 1996·Science·R S Sohal, R Weindruch
Oct 23, 1997·The Journal of Clinical Investigation·D PraticòG A FitzGerald
Jun 9, 1999·Mechanisms of Ageing and Development·S GotoN Ishii
Mar 17, 2000·Free Radical Biology & Medicine·L J Roberts, J D Morrow
Jul 25, 2000·Mechanisms of Ageing and Development·H R WarnerA G Richardson
Aug 23, 2001·Proceedings of the National Academy of Sciences of the United States of America·M L HamiltonA Richardson
May 3, 2002·Clinical and Experimental Pharmacology & Physiology·John J Lehman, Daniel P Kelly
May 3, 2002·Clinical and Experimental Pharmacology & Physiology·Heinrich TaegtmeyerMartin E Young
Jul 12, 2002·American Journal of Physiology. Renal Physiology·Allison A Eddy
Nov 7, 2002·Proceedings of the National Academy of Sciences of the United States of America·Cheol-Koo LeeTomas A Prolla
Jan 9, 2003·Free Radical Research·Ana IndartBartolomé Bonet
Aug 12, 2004·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Huber R Warner
May 12, 2005·Mechanisms of Ageing and Development·Edward J Masoro
Jun 2, 2005·Mechanisms of Ageing and Development·Stephen R Spindler
Jun 3, 2005·The Journal of Nutrition·Eun-Soo Han, Morgen Hickey
Jun 9, 2005·BMC Bioinformatics·Seon-Young Kim, David J Volsky
Aug 5, 2005·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Walter F WardArlan Richardson
Oct 14, 2005·Legal Medicine·Takaki IshikawaHitoshi Maeda
Feb 4, 2006·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Edward J Masoro
Feb 4, 2006·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Jie ChenRunsheng Ruan
May 9, 2006·Antioxidants & Redox Signaling·Hae Young ChungByung Pal Yu
Jun 29, 2006·Annals of the New York Academy of Sciences·Ioannis P TrougakosEfstathios S Gonos
Mar 9, 2007·American Journal of Physiology. Renal Physiology·Susan H McKiernanJudd M Aiken
Jul 31, 2007·Ageing Research Reviews·M Shawkat Razzaque

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Citations

Nov 30, 2012·Annual Review of Physiology·David Gems, Linda Partridge
Jun 8, 2013·Free Radical Biology & Medicine·Michael E WalshHolly Van Remmen

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