Identifying the etiology and pathophysiology underlying stunting and environmental enteropathy: study protocol of the AFRIBIOTA project

BMC Pediatrics
Pascale VonaeschAFRIBIOTA Investigators

Abstract

Globally one out of four children under 5 years is affected by linear growth delay (stunting). This syndrome has severe long-term sequelae including increased risk of illness and mortality and delayed psychomotor development. Stunting is a syndrome that is linked to poor nutrition and repeated infections. To date, the treatment of stunted children is challenging as the underlying etiology and pathophysiological mechanisms remain elusive. We hypothesize that pediatric environmental enteropathy (PEE), a chronic inflammation of the small intestine, plays a major role in the pathophysiology of stunting, failure of nutritional interventions and diminished response to oral vaccines, potentially via changes in the composition of the pro- and eukaryotic intestinal communities. The main objective of AFRIBIOTA is to describe the intestinal dysbiosis observed in the context of stunting and to link it to PEE. Secondary objectives include the identification of the broader socio-economic environment and biological and environmental risk factors for stunting and PEE as well as the testing of a set of easy-to-use candidate biomarkers for PEE. We also assess host outcomes including mucosal and systemic immunity and psychomotor development. This...Continue Reading

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Citations

Aug 23, 2019·Annual Review of Nutrition·Carlos Gómez-GallegoM Carmen Collado
Dec 21, 2019·World Journal of Microbiology & Biotechnology·Habib BokhariAbdul Rauf Siddiqi
Apr 11, 2020·Journal of the American College of Nutrition·Amanat Ali
Aug 22, 2018·Proceedings of the National Academy of Sciences of the United States of America·Pascale VonaeschUNKNOWN Afribiota Investigators
Dec 16, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Seyyed Amir Yasin AhmadiJafar Rezaian
Aug 13, 2021·Maternal and Child Health Journal·Pascale VonaeschUNKNOWN AFRIBIOTA Investigators

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Methods Mentioned

BETA
biopsies
Assay
flow cytometry

Software Mentioned

ED
AFRBIOTA
PROVIDE
AFRIBIOTA
MAL
Antananarivo

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