Identifying the morphologic basis for radiomic features in distinguishing different Gleason grades of prostate cancer on MRI: Preliminary findings.

PloS One
Gregory PenziasAnant Madabhushi

Abstract

Translation of radiomics into the clinic may require a more comprehensive understanding of the underlying morphologic tissue characteristics they reflect. In the context of prostate cancer (PCa), some studies have correlated gross histological measurements of gland lumen, epithelium, and nuclei with disease appearance on MRI. Quantitative histomorphometry (QH), like radiomics for radiologic images, is the computer based extraction of features for describing tumor morphology on digitized tissue images. In this work, we attempt to establish the histomorphometric basis for radiomic features for prostate cancer by (1) identifying the radiomic features from T2w MRI most discriminating of low vs. intermediate/high Gleason score, (2) identifying QH features correlated with the most discriminating radiomic features previously identified, and (3) evaluating the discriminative ability of QH features found to be correlated with spatially co-localized radiomic features. On a cohort of 36 patients (23 for training, 13 for validation), Gabor texture features were identified as being most predictive of Gleason grade on MRI (AUC of 0.69) and gland lumen shape features were identified as the most predictive QH features (AUC = 0.75). Our results...Continue Reading

References

Apr 28, 2000·IEEE Transactions on Medical Imaging·L G NyúlX Zhang
Aug 27, 2005·IEEE Transactions on Pattern Analysis and Machine Intelligence·Hanchuan PengChris Ding
Oct 7, 2006·Medical Physics·Anant Madabhushi, Jayaram K Udupa
Oct 13, 2009·Medical Image Analysis·Cigdem Gunduz-DemirCenk Sokmensuer
Nov 4, 2009·IEEE Transactions on Bio-medical Engineering·Yousef Al-KofahiBadrinath Roysam
Nov 4, 2009·IEEE Transactions on Bio-medical Engineering·Ajay Nagesh BasavanhallyAnant Madabhushi
Dec 17, 2009·The Journal of Urology·Jonathan I Epstein
May 25, 2010·Clinical Chemistry and Laboratory Medicine : CCLM·Anant MadabhushiMichael Feldman
Mar 15, 2011·Computerized Medical Imaging and Graphics : the Official Journal of the Computerized Medical Imaging Society·Jonathan ChappelowAnant Madabhushi
Jan 20, 2012·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Philippe LambinHugo J W L Aerts
Dec 12, 2012·Twin Research and Human Genetics : the Official Journal of the International Society for Twin Studies·Leslie D LeveDavid Reiss
Jan 9, 2013·Medical Image Analysis·Pallavi TiwariAnant Madabhushi
Jul 28, 2013·Computer Vision and Image Understanding : CVIU·Rachel Sparks, Anant Madabhushi
Feb 12, 2014·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Kenneth A MilesAshley M Groves
Apr 25, 2014·IEEE Transactions on Bio-medical Engineering·Mitko VetaMax A Viergever
Dec 4, 2014·Computerized Medical Imaging and Graphics : the Official Journal of the Computerized Medical Imaging Society·Sahirzeeshan AliAnant Madabhushi
Mar 10, 2015·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Thibaud P CorollerHugo J W L Aerts
May 23, 2015·IEEE Transactions on Medical Imaging·Korsuk SirinukunwattanaNasir M Rajpoot
Jun 26, 2015·Journal of Magnetic Resonance Imaging : JMRI·Asha SinganamalliAnant Madabhushi
Aug 8, 2015·Scientific Reports·Chintan ParmarHugo J W L Aerts
Aug 19, 2015·Scientific Reports·Chintan ParmarHugo J W L Aerts
Nov 19, 2015·Proceedings of the National Academy of Sciences of the United States of America·Duc FehrJoseph O Deasy
Nov 19, 2015·Radiology·Robert J GilliesHedvig Hricak
Dec 24, 2015·Frontiers in Oncology·Chintan ParmarHugo J W L Aerts
Mar 28, 2016·Academic Radiology·Habib RahbarChristoph I Lee
Apr 12, 2016·Frontiers in Oncology·Weimiao WuHugo J W L Aerts

❮ Previous
Next ❯

Citations

Feb 23, 2020·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Niha BeigPallavi Tiwari
Feb 2, 2021·Neuro-oncology Advances·Niha BeigPallavi Tiwari
Feb 17, 2021·Nature Biomedical Engineering·Jonathan T C LiuAnant Madabhushi
Mar 18, 2021·Scientific Reports·Tafadzwa L ChaunzwaHugo J W L Aerts
Jun 13, 2020·European Journal of Radiology·Arnaldo StanzioneMassimo Imbriaco
Aug 31, 2021·Journal of Imaging·Giuseppe CutaiaGiuseppe Salvaggio

❮ Previous
Next ❯

Methods Mentioned

BETA
feature extraction

Software Mentioned

ImageScope ( Aperio )

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.