Abstract
We aimed to develop a prediction model to identify long-term survivors after developing distant metastasis from breast cancer. From the institution's database, we collected data of 547 patients who developed distant metastasis during their follow-ups. We developed a model that predicts the post-metastasis overall survival (PMOS) based on the clinicopathologic factors of the primary tumors and the characteristics of the distant metastasis. For validation, the survival data of 254 patients from four independent institutions were used. The median duration of the PMOS was 31.0 months. The characteristics of the initial primary tumor, such as tumor stage, hormone receptor status, and Ki-67 expression level, and the characteristics of the distant metastasis presentation including the duration of disease-free interval, the site of metastasis, and the presence of metastasis-related symptoms were independent prognostic factors determining the PMOS. The association between tumor stage and the PMOS was only seen in tumors with early relapses. The PMOS score, which was developed based on the above six factors, successfully identified patients with superior survival after metastasis. The median PMOS for patients with a PMOS score of <2 and ...Continue Reading
References
Jan 1, 1992·Breast Cancer Research and Treatment·P G KoendersT J Benraad
Jan 1, 1987·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·G M ClarkW L McGuire
Mar 1, 1983·Annals of Surgery·M D GillilandE M Copeland
May 18, 1999·Breast Cancer Research and Treatment·O JuanJ Garcia-Conde
Oct 12, 1999·Breast Cancer Research and Treatment·A InsaJ Garcia-Conde
Feb 1, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Yago NietoScott I Bearman
Feb 22, 2002·The Breast Journal·Edgardo RiveraGabriel N Hortobagyi
Jan 28, 2003·Cancer·Jenny ChangRichard M Elledge
Jul 3, 2003·JAMA : the Journal of the American Medical Association·Elizabeth B Lamont, Nicholas A Christakis
Dec 24, 2003·Cancer·Sharon H GiordanoGabriel N Hortobagyi
Dec 25, 2003·Breast Cancer Research and Treatment·Brigitte RackKlaus Friese
May 1, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Rebecca G HagertyMartin H N Tattersall
Aug 18, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Fabrice AndreMarc Spielmann
Jul 28, 2005·Cancer·Emer O HanrahanEdgardo Rivera
Oct 28, 2005·The New England Journal of Medicine·Donald A BerryUNKNOWN Cancer Intervention and Surveillance Modeling Network (CISNET) Collaborators
Jul 25, 2007·Cancer·Stephen K ChiaIvo A Olivotto
Jul 22, 2008·Annals of Oncology : Official Journal of the European Society for Medical Oncology·R LargillierE Chamorey
Aug 30, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Shaheenah DawoodSharon H Giordano
Oct 7, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Hyeong-Gon MoonDong-Young Noh
Mar 12, 2010·Journal of the National Cancer Institute·Olivia PaganiUNKNOWN ESO-MBC Task Force
Apr 30, 2010·Annals of Oncology : Official Journal of the European Society for Medical Oncology·S DawoodS H Giordano
Mar 1, 2012·The Lancet Oncology·Saskia LitièreHarry Bartelink
Oct 24, 2012·Breast Cancer Research : BCR·Bas FrankenLeon W M M Terstappen
Jan 22, 2013·CA: a Cancer Journal for Clinicians·Rebecca SiegelAhmedin Jemal
Nov 10, 2013·Journal of the National Cancer Institute·Mei-Yin C PolleyUNKNOWN International Ki67 in Breast Cancer Working Group of the Breast International Group and North American Breast Cancer Group
Mar 13, 2015·Cancer Research and Treatment : Official Journal of Korean Cancer Association·Kyu-Won JungKang Hyun Lee
Mar 31, 2015·Breast Cancer Research and Treatment·C Dilara Savci-HeijinkMarc J van de Vijver
Sep 30, 2015·Nature·Devon A LawsonZena Werb
Citations
Mar 28, 2017·Scientific Reports·Yue GongZhi-Ming Shao
Oct 6, 2017·Cancer Medicine·Shunrong LiKai Chen
Jan 16, 2018·Cancer Research and Treatment : Official Journal of Korean Cancer Association·Zhenchong XiongXi Wang
Jun 20, 2020·Therapeutic Advances in Medical Oncology·Zheng WangKunwei Shen
Sep 16, 2018·Breast Cancer Research and Treatment·Jai Min RyuSeok Won Kim
Aug 28, 2020·Frontiers in Oncology·Yujie LuKunwei Shen
Sep 19, 2020·Polski przeglad chirurgiczny·Joanna PakułaKrzysztof Kuzdak
Oct 14, 2020·BMC Cancer·Wen ZhaoJin Yang
Aug 13, 2020·Breast Cancer Research and Treatment·Richard S FinnHope S Rugo
Feb 4, 2021·Scientific Reports·Jong-Ho CheunHyeong-Gon Moon
Feb 14, 2021·Medicine·Niuniu HouRui Ling
Dec 10, 2020·Aging·Ming XuZhenhua Lin
Nov 4, 2021·BMC Cancer·Yizhao XieXichun Hu