Identifying the potential long-term survivors among breast cancer patients with distant metastasis.

Annals of Oncology : Official Journal of the European Society for Medical Oncology
E S LeeH G Moon

Abstract

We aimed to develop a prediction model to identify long-term survivors after developing distant metastasis from breast cancer. From the institution's database, we collected data of 547 patients who developed distant metastasis during their follow-ups. We developed a model that predicts the post-metastasis overall survival (PMOS) based on the clinicopathologic factors of the primary tumors and the characteristics of the distant metastasis. For validation, the survival data of 254 patients from four independent institutions were used. The median duration of the PMOS was 31.0 months. The characteristics of the initial primary tumor, such as tumor stage, hormone receptor status, and Ki-67 expression level, and the characteristics of the distant metastasis presentation including the duration of disease-free interval, the site of metastasis, and the presence of metastasis-related symptoms were independent prognostic factors determining the PMOS. The association between tumor stage and the PMOS was only seen in tumors with early relapses. The PMOS score, which was developed based on the above six factors, successfully identified patients with superior survival after metastasis. The median PMOS for patients with a PMOS score of <2 and ...Continue Reading

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Citations

Jan 16, 2018·Cancer Research and Treatment : Official Journal of Korean Cancer Association·Zhenchong XiongXi Wang
Sep 16, 2018·Breast Cancer Research and Treatment·Jai Min RyuSeok Won Kim
Sep 19, 2020·Polski przeglad chirurgiczny·Joanna PakułaKrzysztof Kuzdak
Feb 4, 2021·Scientific Reports·Jong-Ho CheunHyeong-Gon Moon

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