Identifying the threshold of iron deficiency in the central nervous system of the rat by the auditory brainstem response

ASN Neuro
Allison R Greminger, Margot Mayer-Pröschel

Abstract

The deleterious effects of anemia on auditory nerve (AN) development have been well investigated; however, we have previously reported that significant functional consequences in the auditory brainstem response (ABR) can also occur as a consequence of marginal iron deficiency (ID). As the ABR has widespread clinical use, we evaluated the ability of this electrophysiological method to characterize the threshold of tissue ID in rats by examining the relationship between markers of tissue ID and severity of ABR latency defects. To generate various levels of ID, female Long-Evans rats were exposed to diets containing sufficient, borderline, or deficient iron (Fe) concentrations throughout gestation and offspring lifetime. We measured hematological indices of whole body iron stores in dams and offspring to assess the degree of ID. Progression of AN ID in the offspring was measured as ferritin protein levels at different times during postnatal development to complement ABR functional measurements. The severity of ABR deficits correlated with the level of Fe restriction in each diet. The sufficient Fe diet did not induce AN ID and consequently did not show an impaired ABR latency response. The borderline Fe diet, which depleted AN Fe ...Continue Reading

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Citations

Oct 9, 2018·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Mohsen Saleh ElAlfyNoha Ahmed Mokhtar
Jan 17, 2017·Molecular Neurobiology·Maria Victoria Rosato-SiriJuana Maria Pasquini
Oct 21, 2018·Pediatric Research·Amanda BarksMichael K Georgieff

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Methods Mentioned

BETA
Protein Assay

Software Mentioned

ImageJ
SmartEP

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