Identifying tumor vascular permeability heterogeneity with magnetic resonance imaging contrast agents

Investigative Radiology
Michael ArefE C Wiener

Abstract

Dynamic contrast enhanced (DCE) MR mammography (MRM) uses tumor capillary density differences for prognosis. The heterogeneous response of permeability-surface area products (PS = Kp<-->t) was examined in mammary tumors, as a function of contrast agent size, to determine what effect ROI size might have on PS and prognosis. DCE FLASH signal intensities were converted to gadolinium concentrations by a standard curve, which was fitted by a two-compartment model for the tumor's extravascular extracellular space (EES) volume fraction (ve), and the tumor volume normalized transfer rate between plasma and EES (Kp<-->t/VT). For Gd-DTPA ve = 9% to 13% Kp<-->t/VT = 0.01 to 0.06 minutes-1, and the macromolecular agent, PAMAM-TU-DTPA G = 4 ve = 0.8% to 1% Kp<-->t/VT = 0.008 to 0.04 minutes(-1). Significant differences in Kp<-->t/VT for local regions were found for both agents relative to the whole tumor and the macromolecular agent had greater dynamic range. Smaller ROI values or pixels should yield more accurate assessment of neovascularization.

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Citations

Jul 14, 2011·Annals of Biomedical Engineering·Gregory L PishkoMalisa Sarntinoranont
Sep 26, 2008·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Marie Poirier-QuinotLuc Darrasse
Oct 6, 2011·Journal of Magnetic Resonance Imaging : JMRI·Tong San KohChoon Hua Thng
Jan 16, 2007·Magnetic Resonance Imaging·Michael ArefErik C Wiener
Sep 18, 2012·Microvascular Research·Gregory L PishkoMalisa Sarntinoranont
Nov 25, 2003·Investigative Radiology·Val M Runge
Jan 16, 2009·Contrast Media & Molecular Imaging·Melanie HeilmannAndreas Volk
Jun 24, 2005·Investigative Radiology·Dorothee R FischerWerner A Kaiser
Dec 24, 2002·Investigative Radiology·Stefan O R PfleidererWerner A Kaiser
Jun 21, 2012·Clinical Pharmacology and Therapeutics·A J Atkinson, B P Smith
Jun 15, 2016·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Yongmin ChangYoung Mo Kang

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