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Identity-by-descent-based heritability analysis in the Northern Finland Birth Cohort

Human Genetics

Oct 12, 2012

Sharon R Browning, Brian L Browning

Abstract

For most complex traits, only a small proportion of heritability is explained by statistically significant associations from genome-wide association studies (GWAS). In order to determine how much heritability can potentially be explained through larger GWAS, several different approaches...read more

Mentioned in this Paper

Metabolic Process, Cellular
Genome-Wide Association Study
In Silico
Low Density Lipoprotein Cholesterol Measurement
Serum HDL Cholesterol Measurement
European Continental Ancestry Group
High Density Lipoprotein Measurement
Oligogenic Inheritance
Quantitative Trait, Heritable
High Density Lipoprotein Cholesterol
62
Paper Details
References
  • References26
  • Citations10
123
  • References26
  • Citations10
1

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Identity-by-descent-based heritability analysis in the Northern Finland Birth Cohort

Human Genetics

Oct 12, 2012

Sharon R Browning, Brian L Browning

PMID: 23052944

DOI: 10.1007/s00439-012-1230-y

Abstract

For most complex traits, only a small proportion of heritability is explained by statistically significant associations from genome-wide association studies (GWAS). In order to determine how much heritability can potentially be explained through larger GWAS, several different approaches...read more

Mentioned in this Paper

Metabolic Process, Cellular
Genome-Wide Association Study
In Silico
Low Density Lipoprotein Cholesterol Measurement
Serum HDL Cholesterol Measurement
European Continental Ancestry Group
High Density Lipoprotein Measurement
Oligogenic Inheritance
Quantitative Trait, Heritable
High Density Lipoprotein Cholesterol
62

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Cholesterol Synthesis & Signaling

Cholesterol is essential for a variety of cellular processes, including cell growth and division, and it plays an important role in various signaling pathways. Here is the latest research on cholesterol synthesis and the role of cholesterol in cell signaling.

Related Papers

BMC Ophthalmology

The Northern Finland Birth Cohort Eye Study: Design and baseline characteristics

BMC OphthalmologyOctober 10, 2013
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Re-sequencing expands our understanding of the phenotypic impact of variants at GWAS loci

PLoS GeneticsFebruary 6, 2014
Susan K ServiceNelson B Freimer
Paper Details
References
  • References26
  • Citations10
123
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1
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