Identity of GA1, GM1a and GD1b synthase in Golgi vesicles from rat liver

FEBS Letters
H IberK Sandhoff

Abstract

Synthesis of ganglioside GD1b from ganglioside GD2 was demonstrated using Golgi membranes isolated from rat liver. Competition experiments using gangliosides GA2, GM2 and GD2 as substrates, and as mutual inhibitors for ganglioside galactosyltransferase activity in preparations of Golgi vesicles derived from rat liver, suggested that galactosyl transfer to these three compounds, leading to gangliosides GA1, GM1a and GD1b respectively, is catalyzed by one enzyme. These results strengthen the hypothesis that the main site for the regulation of ganglioside biosynthesis occurs within the reaction sequence LacCer----GA3----GD3----GT3.

References

Sep 15, 1987·European Journal of Biochemistry·D KleinK Sandhoff
Oct 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·G PohlentzK Sandhoff
Jan 1, 1988·Biological Chemistry Hoppe-Seyler·G PohlentzK Sandhoff
Oct 1, 1986·European Journal of Biochemistry·K Busam, K Decker
Dec 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·H K YusufK Sandhoff
Sep 1, 1963·Journal of Neurochemistry·L SVENNERHOLM

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Citations

Feb 5, 1991·Biochimica Et Biophysica Acta·J GottfriesL Svennerholm
May 1, 1991·Journal of Neurochemistry·A K PercyL Svennerholm
Apr 1, 1991·Journal of Neurosurgery·F A RoddenB L Bauer
Dec 11, 1990·Biochemistry·G Schwarzmann, K Sandhoff
Jan 1, 2012·ISRN Biochemistry·Thomas Kolter
Aug 31, 1990·Biochemical and Biophysical Research Communications·M Mesarić, K Decker

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