IDH-mutated astrocytomas with 19q-loss constitute a subgroup that confers better prognosis

Cancer Science
Ryohei OtaniKeisuke Ueki

Abstract

IDH-mutant gliomas are classified into astrocytic or oligodendroglial tumors by 1p/19q status in the WHO 2016 classification, with the latter presenting with characteristic morphology and better prognosis in general. However, the morphological and genetic features within each category are varied, and there might be distinguishable subtypes. We analyzed 170 WHO grade II-IV gliomas resected in our institution. 1p/19q status was analyzed by microsatellite analysis, and genetic mutations were analyzed by next-generation sequencing and Sanger sequencing. For validation, the Brain Lower Grade Glioma dataset of The Cancer Genome Atlas was analyzed. Of the 42 grade III IDH-mutated gliomas, 12 were 1p-intact/19q-intact (anaplastic astrocytomas [AA]), 7 were 1p-intact/19q-loss (AA), and 23 showed 1p/19q-codeletion (anaplastic oligodendrogliomas). Of the 88 IDH-wild type glioblastomas (GBMs), 14 showed 1p-intact/19q-loss status. All of the seven 1p-intact/19q-loss AAs harbored TP53 mutation, but no TERT promotor mutation. All 19q-loss AAs had regions presenting oligodendroglioma-like morphology, and were associated with significantly longer overall survival compared to 19q-intact AAs (P = .001). This tendency was observed in The Cancer Ge...Continue Reading

References

Oct 17, 1998·Neuropathology and Applied Neurobiology·S B WhartonJ R Anderson
Oct 17, 1998·Journal of the National Cancer Institute·J G CairncrossD N Louis
Nov 15, 2002·Journal of Neuropathology and Experimental Neurology·Arie PerryJohan M Kros
Sep 11, 2008·Journal of Neuro-oncology·Hiroaki TakeuchiKazufumi Sato
Aug 6, 2011·Science·Chetan BettegowdaKenneth W Kinzler
Oct 17, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Martin J van den BentKhê Hoang-Xuan
Oct 17, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Gregory CairncrossMinesh Mehta
Sep 24, 2013·Human Pathology·Takanori HiroseAtsushi Sasaki
Apr 8, 2015·Nature Genetics·Hiromichi SuzukiSeishi Ogawa
Mar 9, 2017·Acta Neuropathologica Communications·Koki AiharaNobuhito Saito

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Citations

Nov 7, 2019·International Journal of Cancer. Journal International Du Cancer·Anna P SokolenkoEvgeny N Imyanitov
Jan 13, 2021·Journal of Neuropathology and Experimental Neurology·Yohei MiyakeTetsuya Yamamoto
Aug 31, 2021·Frontiers in Cell and Developmental Biology·Xingang ZhouPeng Wang

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Methods Mentioned

BETA
PCR
Chip
exome sequencing

Software Mentioned

SPSS
Torrent Suite

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