Abstract
Acquisition of IDH1 or IDH2 mutation (IDHmut) is among the earliest genetic events that take place in the development of most low-grade glioma (LGG). IDHmut has been associated with longer overall patient survival. However, its impact on malignant transformation (MT) remains to be defined. A collection of 210 archived adult LGG previously stratified by IDHmut, MGMT methylation (MGMTmet), 1p/19q combined loss of heterozygosity (1p19qloh) and TP53 immunopositivity (TP53pos) status was analyzed. We used multistate models to assess MT-free survival, considering one initial, one transient (MT), and one absorbing state (death). Missing explanatory variables were multiply imputed. Overall, although associated with a lower risk of death (HR(DEATH) = 0.35, P = 0.0023), IDHmut had a non-significantly higher risk of MT (HR(MT) = 1.84; P = 0.1683) compared to IDH wild type (IDHwt). The double combination of IDHmut and MGMTmet and the triple combination of IDHmut, MGMTmet and 1p/19qloh, despite significantly lower hazards for death (HR(DEATH) versus IDHwt: 0.35, P = 0.0194 and 0.15, P = 0.0008, respectively), had non-significantly different hazards for MT. Conversely, the triple combination of IDHmut/MGMTmet/TP53pos, with a non-significantl...Continue Reading
References
Jul 1, 1993·Brain Pathology·P KleihuesB W Scheithauer
Apr 1, 1997·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·C LeightonG Cairncross
Apr 17, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Francesco PignattiUNKNOWN European Organization for Research and Treatment of Cancer Radiotherapy Cooperative Group
May 1, 2004·Acta Neuropathologica·Yoshikazu OkamotoHiroko Ohgaki
Oct 7, 2004·Cancer Research·Hiroko OhgakiPaul Kleihues
Mar 11, 2005·The New England Journal of Medicine·Monika E HegiRoger Stupp
Jun 28, 2005·Journal of Neuropathology and Experimental Neurology·Hiroko Ohgaki, Paul Kleihues
Sep 13, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Luigi MarianiMichael M Reinert
Oct 13, 2006·Statistics in Medicine·H PutterR B Geskus
Jul 10, 2007·Acta Neuropathologica·David N LouisPaul Kleihues
Sep 6, 2008·Science·D Williams ParsonsKenneth W Kinzler
Feb 21, 2009·The New England Journal of Medicine·Hai YanDarell D Bigner
Feb 28, 2009·The American Journal of Pathology·Takuya WatanabeHiroko Ohgaki
Jul 29, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Marc SansonJean-Yves Delattre
Sep 17, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Sumihito NobusawaHiroko Ohgaki
Nov 26, 2009·Neurology·H J DubbinkM J van den Bent
Nov 26, 2009·Nature·Lenny DangShinsan M Su
Apr 20, 2010·Cancer Cell·Houtan NoushmehrUNKNOWN Cancer Genome Atlas Research Network
Oct 27, 2010·Neurology·C HouillierJ-Y Delattre
Nov 16, 2010·The American Journal of Pathology·Young-Ho KimHiroko Ohgaki
Jun 7, 2011·Journal of Neuro-oncology·Marta MellaiDavide Schiffer
Aug 6, 2011·Science·Chetan BettegowdaKenneth W Kinzler
Feb 22, 2012·Nature·Sevin TurcanTimothy A Chan
Feb 22, 2012·Nature·Chao LuCraig B Thompson
Feb 15, 2013·Neuro-oncology·Severina LeuLuigi Mariani
Jul 31, 2013·PloS One·Peng ZouAihua Gu
Aug 13, 2013·Journal of Neuro-oncology·Yazmin OdiaFausto J Rodriguez
Apr 10, 2014·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Hiroaki WakimotoAndrew S Chi
Jun 11, 2015·The New England Journal of Medicine·UNKNOWN Cancer Genome Atlas Research NetworkJianan Zhang
Jun 11, 2015·The New England Journal of Medicine·Jeanette E Eckel-PassowRobert B Jenkins
Citations
Feb 15, 2019·Science Translational Medicine·Felipe J NúñezMaria G Castro
Jan 30, 2020·PloS One·Nahla A MobarkMalak Abedalthagafi
Apr 5, 2020·Neurological Research·Jin ZhuYu-Qi Zhang
Jun 21, 2017·Metabolites·Thomas LeatherHarish Poptani
Feb 17, 2018·Neuro-oncology·Serah ChoiJoseph F Costello
Jan 22, 2020·Expert Opinion on Biological Therapy·David B AltshulerMaria G Castro
Aug 18, 2020·BioMed Research International·Jingwei ZhaoBo Wei
Sep 28, 2017·Cancer Biomarkers : Section a of Disease Markers·Xianliang LaiWei Tu
Jan 19, 2020·Cancers·Marek MazurekCezary Grochowski
Jan 18, 2018·CNS Neuroscience & Therapeutics·Tao ZhuZhao-Qian Liu
Nov 14, 2018·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Jehan AlRayahiSuzanne Laughlin
May 21, 2017·Journal of Neuro-oncology·Chikezie I EseonuAlfredo Quinones-Hinojosa
Aug 31, 2016·Neuro-oncology·Michael WahlSusan M Chang
Jan 1, 2017·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Prajwal RajappaJeffrey P Greenfield
Dec 18, 2020·The Journal of Clinical Investigation·Padma KadiyalaMaria G Castro
Jun 18, 2017·Biochemical and Biophysical Research Communications·Xianliang LaiWei Tu
Apr 19, 2021·World Neurosurgery·Aleksandra B LasicaGeorge Samandouras
May 14, 2021·Frontiers in Oncology·Jinxiu GuoYubing Zhou
May 25, 2021·PeerJ·Jieting LiuKehu Yang
Sep 2, 2021·Neuro-oncology Advances·Zabina SatarGeorge Samandouras
Nov 10, 2020·Neurocirugía·Pedro Valente AguiarPaulo Linhares