IDH mutation status is associated with distinct vascular gene expression signatures in lower-grade gliomas.

Neuro-oncology
Lei ZhangAnna Dimberg

Abstract

Vascular gene expression patterns in lower-grade gliomas (LGGs; diffuse World Health Organization [WHO] grades II-III gliomas) have not been thoroughly investigated. The aim of this study was to molecularly characterize LGG vessels and determine if tumor isocitrate dehydrogenase (IDH) mutation status affects vascular phenotype. Gene expression was analyzed using an in-house dataset derived from microdissected vessels and total tumor samples from human glioma in combination with expression data from 289 LGG samples available in the database of The Cancer Genome Atlas. Vascular protein expression was examined by immunohistochemistry in human brain tumor tissue microarrays (TMAs) representing WHO grades II-IV gliomas and nonmalignant brain samples. Regulation of gene expression was examined in primary endothelial cells in vitro. Gene expression analysis of WHO grade II glioma indicated an intermediate stage of vascular abnormality, less severe than that of glioblastoma vessels but distinct from normal vessels. Enhanced expression of laminin subunit alpha 4 (LAMA4) and angiopoietin 2 (ANGPT2) in WHO grade II glioma was confirmed by staining of human TMAs. IDH wild-type LGGs displayed a specific angiogenic gene expression signature,...Continue Reading

References

Jul 28, 2004·The American Journal of Pathology·Stephen L MaddenKevin A Walter
Dec 31, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Teri N KreislHoward A Fine
Feb 21, 2009·The New England Journal of Medicine·Hai YanDarell D Bigner
Sep 2, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Henry S FriedmanTimothy Cloughesy
Nov 19, 2009·Cancer Research·Lonneke A M GravendeelPim J French
Jan 20, 2011·Surgical Neurology International·Patrick J Kelly
May 12, 2011·British Journal of Cancer·T ElsirA Smits
Oct 17, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Martin J van den BentKhê Hoang-Xuan
Jan 15, 2014·Histopathology·Svetlana N PopovaIrina Alafuzoff
Jun 20, 2014·Nature Communications·Stacey WatkinsHarald Sontheimer
Aug 3, 2014·Cancer Discovery·Laura RodónJoan Seoane
Nov 18, 2014·Biochemical Society Transactions·Anna Dimberg
Jan 2, 2015·Neurosurgical Focus·Elizabeth B ClausMargaret Wrensch
Mar 12, 2015·Brain Pathology·Zhe Bao WuWei Guo Zhao
Mar 17, 2015·Annals of the New York Academy of Sciences·Alexander ScholzYvonne Reiss
Jun 11, 2015·The New England Journal of Medicine·UNKNOWN Cancer Genome Atlas Research NetworkJianan Zhang
Jan 16, 2016·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Nicholas P TobinJonas Bergh
Feb 10, 2016·Oncotarget·Elisa PaolicchiStefano Landi
Sep 17, 2016·Journal of Neuro-oncology·Siobhan ConroyWilfred F A den Dunnen
Nov 3, 2016·Current Opinion in Neurology·Andreas F HottingerBrigitta G Baumert
Jan 17, 2017·Molecular & Cellular Oncology·Lei Zhang, Anna Dimberg
Mar 13, 2017·The American Journal of Pathology·Sean MahaseDavid Zagzag
May 10, 2017·The Lancet Oncology·Michael WellerUNKNOWN European Association for Neuro-Oncology (EANO) Task Force on Gliomas
Feb 15, 2018·Nature·Michael VanlandewijckChrister Betsholtz

❮ Previous
Next ❯

Citations

Mar 13, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Bozena KaminskaBartlomiej Gielniewski
Nov 12, 2019·Journal of Cellular Biochemistry·Meenakshi VachherBhupender Kumar
Nov 20, 2019·Oncotarget·Shelli R KeslerJohn de Groot
Oct 22, 2019·Frontiers in Immunology·Lucas J M Perus, Logan A Walsh
Nov 6, 2018·International Journal of Oncology·Xuejun DaiRuisheng Lin
Nov 7, 2019·Cellular and Molecular Life Sciences : CMLS·Roberta LuganoAnna Dimberg
Oct 3, 2019·Cells·Cintia Carla da HoraBakhos A Tannous
Jan 11, 2019·Frontiers in Immunology·Maria GeorganakiAnna Dimberg
Nov 12, 2020·Biology·Kyra E de GoedeJan Van den Bossche
Oct 30, 2020·Cancer Management and Research·Houyi KangWeiguo Zhang
Jul 3, 2021·International Journal of Molecular Sciences·Sara Rosińska, Julie Gavard
Aug 28, 2021·Cancers·Georgios C ManikisKostas Marias
Dec 7, 2021·Pathology Oncology Research : POR·Jiefu TangMinjiang Huang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.

Arterial-Venous in Development & Disease

Arterial-venous development may play a crucial role in cardiovascular diseases. Here is the latest research.

Related Papers

Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology
Harun M SaidDirk Vordermark
Zhonghua bing li xue za zhi Chinese journal of pathology
Yi PanYan-feng Zhong
Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology
Jiankuan ShiJing Ye
© 2022 Meta ULC. All rights reserved