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IDH1 and IDH2 mutations as novel therapeutic targets: current perspectives

Journal of Blood Medicine

Sep 14, 2016

Johanna MondesirStéphane De Botton

Abstract

Isocitrate dehydrogenase 1 and 2 (IDH1 and IDH2) are key metabolic enzymes that convert isocitrate to α-ketoglutarate. IDH1/2 mutations define distinct subsets of cancers, including low-grade gliomas and secondary glioblastomas, chondrosarcomas, intrahepatic cholangiocarcinomas, and hem...read more

Mentioned in this Paper

Biological Markers
Chondrosarcoma
Metabolic Process, Cellular
Histone antigen
Secondary Glioblastoma
Hematologic Neoplasms
Enzymes, antithrombotic
Isocitrate
Alpha Ketoglutarate
Cholangiocarcinoma
1
141
1
Paper Details
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IDH1 and IDH2 mutations as novel therapeutic targets: current perspectives

Journal of Blood Medicine

Sep 14, 2016

Johanna MondesirStéphane De Botton

PMID: 27621679

DOI: 10.2147/jbm.s70716

Abstract

Isocitrate dehydrogenase 1 and 2 (IDH1 and IDH2) are key metabolic enzymes that convert isocitrate to α-ketoglutarate. IDH1/2 mutations define distinct subsets of cancers, including low-grade gliomas and secondary glioblastomas, chondrosarcomas, intrahepatic cholangiocarcinomas, and hem...read more

Mentioned in this Paper

Biological Markers
Chondrosarcoma
Metabolic Process, Cellular
Histone antigen
Secondary Glioblastoma
Hematologic Neoplasms
Enzymes, antithrombotic
Isocitrate
Alpha Ketoglutarate
Cholangiocarcinoma
1
141
1

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Paper Details
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  • Citations21
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  • Citations21
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