IDH1 mutation-associated long non-coding RNA expression profile changes in glioma

Journal of Neuro-oncology
Xiao-Qin ZhangGilberto Ka-Kit Leung

Abstract

Isocitrate dehydrogenase 1 (IDH1) mutation is an important prognostic marker in glioma. However, its downstream effect remains incompletely understood. Long non-coding RNAs (lncRNAs) are emerging as important regulators of tumorigenesis in a number of human malignancies, including glioma. Here, we investigated whether and how lncRNA expression profiles would differ between gliomas with or without IDH1 mutation. By using our previously reported lncRNA mining approach, we performed lncRNA profiling in three public glioma microarray datasets. The differential lncRNA expression analysis was then conducted between mutant-type and wild-type IDH1 glioma samples. Comparison analysis identified 14 and 9 lncRNA probe sets that showed significantly altered expressions in astrocytic and oligodendroglial tumors, respectively (fold change ≥ 1.5, false discovery rate ≤ 0.1). Moreover, the differential expressions of these lncRNAs could be confirmed in the independent testing sets. Functional exploration of the lncRNAs by analyzing the lncRNA-protein interactions revealed that these IDH1 mutation-associated lncRNAs were involved in multiple tumor-associated cellular processes, including metabolism, cell growth and apoptosis. Our data suggest t...Continue Reading

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Citations

Mar 7, 2019·Frontiers in Genetics·Xiaofeng HuXu Liu
Jan 13, 2017·Topics in Magnetic Resonance Imaging : TMRI·Ahmed HassanPascal Olivier Zinn
Mar 16, 2017·Frontiers in Molecular Neuroscience·Yuanliang YanZhicheng Gong
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Oct 31, 2020·International Journal of Molecular Sciences·Daina SkiriutePaulina Vaitkiene
Sep 10, 2020·Molecular Pharmaceutics·Prabhjeet SinghDeepak Chitkara

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