IDH1/2 mutation status combined with Ki-67 labeling index defines distinct prognostic groups in glioma.

Oncotarget
Ailiang ZengYongping You

Abstract

The current World Health Organization (WHO) classification of human gliomas is mainly based on morphology. However, it has limitations in prognostic prediction. We examined whether combining isocitrate dehydrogenase (IDH) 1/2 mutation status with the Ki-67 labeling index would improve the definition of prognostically distinct entities. We investigated the correlation of Ki-67 expression with IDH1/2 mutation status and their impact on clinical outcome in 703 gliomas. Low Ki-67 expression closely overlapped with IDH1/2 mutation in our cohort (P < 0.0001). Patients with IDH1/2 mutation survived significantly longer than patients with wild-type IDH1/2 did (P < 0.0001); higher Ki-67 expression was associated with shorter progression-free survival and overall survival (OS) (P < 0.0001). IDH1/2 combined with Ki-67 was used to re-classify glioma patients into five groups. IDH1/2 mutant patients with low and moderate Ki-67 expression (Group1) had the best prognosis, whereas patients with wild-type IDH1/2 and high Ki-67 expression (Group5) had the worst prognosis (Median OS = 1527 vs. 355 days, P < 0.0001). To summarize, our new classification model distinguishes biologically distinct subgroups and provides prognostic information regardl...Continue Reading

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Citations

Feb 15, 2020·Neuro-oncology·Vivek TiwariChangho Choi
Dec 24, 2019·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Mohammed GoryawalaAndrew A Maudsley
Sep 14, 2017·Journal of Neuro-oncology·Yiming LiTao Jiang
Apr 24, 2020·Molecular Medicine Reports·Jing ZhouHongmei Fu
Sep 5, 2017·Cancer Biomarkers : Section a of Disease Markers·Mingrong ZuoYanhui Liu
Jul 9, 2020·International Journal of Molecular Sciences·Susannah HallalKimberley Louise Alexander-Kaufman
Aug 11, 2020·Frontiers in Oncology·Yang AnXiangqian Guo
Mar 16, 2017·European Journal of Nuclear Medicine and Molecular Imaging·A VergerE Guedj
Mar 14, 2018·Cell Death & Disease·Ailiang ZengYongping You
Jan 1, 2017·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Prajwal RajappaJeffrey P Greenfield

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Methods Mentioned

BETA
surgical resection
PCR

Software Mentioned

GraphPad Prism

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