PMID: 11899033Mar 20, 2002Paper

Idiopathic asymptomatic thrombocytopenia in Cavalier King Charles Spaniels is an autosomal recessive trait

Journal of Veterinary Internal Medicine
H D PedersenHeidi Larsen

Abstract

Cavalier King Charles Spaniels (CKCS) often have idiopathic asymptomatic thrombocytopenia. In affected dogs, the thrombocytes often are large, and it has been speculated that the condition could be an inherited macrothrombocytopenia. The aim of this study was to examine the inheritance of idiopathic, asymptomatic thrombocytopenia in CKCS. Sixteen families (both parents and > or = 3 offspring) of privately owned CKCS were included. There were 105 clinically healthy dogs (50 from Denmark and 55 from Sweden): 81 offspring and 26 parents (2 dogs had both roles). Because autoanalyzers have difficulty counting large platelets, the platelets were counted manually, with a counting chamber. Platelet counts were not influenced by age, gender, or heart murmur status. Thrombocytopenia (< or = 100,000 platelets/microL) was found in 46% of the parents. The pedigrees indicated that thrombocytopenia segregated as an autosomal recessive trait and that 100,000 platelets/microL was appropriate as a lower limit of normal. Affected offspring were found in all families, showing that all of the included parents were at least carriers. Therefore, the expected segregation ratios (which were in good accordance with the observed ones) were 1:0, 1:1, and ...Continue Reading

Citations

Jan 6, 2005·American Journal of Veterinary Research·Inge TarnowHenrik D Pedersen
Oct 17, 2008·Journal of the American Veterinary Medical Association·Mary K Boudreaux
Dec 1, 2005·Australian Veterinary Journal·M K Singh, W A Lamb
Oct 8, 2003·Journal of Veterinary Internal Medicine·Inge TarnowHenrik D Pedersen
Jun 5, 2007·The Journal of Small Animal Practice·W BertazzoloS Paltrinieri
Jul 20, 2013·Journal of Veterinary Internal Medicine·I LjungvallJ Häggström
Feb 10, 2012·Journal of Veterinary Emergency and Critical Care·Mary K Boudreaux
Jul 26, 2014·Veterinary Clinical Pathology·Maria Elena GelainMary K Boudreaux
Sep 3, 2008·Veterinary Clinical Pathology·Harold TvedtenJens Häggström
Sep 17, 2008·The Journal of Small Animal Practice·N X BommerA E Ridyard

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