PMID: 20649100Jul 24, 2010Paper

Idiopathic CD4+ T-lymphocytopenia--a diagnostic dilemma

The Journal of the Association of Physicians of India
Rohan AugustineSuresh Hegde

Abstract

The devastating global impact of acquired immunodeficiency syndrome (AIDS) has greatly sensitized the public to the threat of new microbes that are capable of wrecking havoc on the world's population. The HIV virus infects and depletes CD4+ T lymphocytes. However cases have been described with profound CD4+ T cell lymphocytopenia but without evidence of HIV infection, a condition now termed as "Idiopathic CD4+ T-Lymphocytopenia". This unexpected revelation at the Ninth International AIDS Conference in Amsterdam was a cause of great public concern and extra ordinary media attention. Hence the Centre for Disease Control and Prevention in Atlanta (CDC) reviewed 23179 cases in the CDC AIDS reporting registry and performed interviews medical record reviews and laboratory analysis of blood specimens and finally identified 47 cases that met the CDC case definition of idiopathic CD4+ T cell lymphocytopenia (<300 CD4+Tcells/cumm or a CD4+ cell count <20% of the total T cell on two occasions, no evidence of infection on HIV testing, absence of any defined immunodeficiency or therapy associated with depressed levels of CD4+ T cells). We are hereby reporting one such case we encountered at our centre who presented with monoparesis and subs...Continue Reading

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.