PMID: 8948372Dec 1, 1996Paper

Idiopathic genital ulcers in women infected with human immunodeficiency virus

Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology : Official Publication of the International Retrovirology Association
J AndersonP Boyer

Abstract

A national survey of investigators caring for human immunodeficiency virus (HIV)-infected women was undertaken to describe the clinical presentation of idiopathic genital ulcer disease. Patients with negative syphilis and herpes simplex testing and/or negative genital ulcer biopsy were included in this study. Study participants (n = 29) were generally severely immunocompromised (median CD4 cell count was 50/mm3, and 68% had an acquired immunodeficiency syndrome [AIDS]-defining opportunistic process). Thirty-seven percent had coexistent oral ulcers and 19% had their genital ulcer progress to fistula formation (four rectovaginal and one vaginal-perineal). There was generally a favorable response to topical, systemic, and intralesional steroid treatment. This study suggests that idiopathic or probable aphthous genital ulcers in women have similar clinical characteristics to aphthous oroesophageal ulcers. Although infrequent, these genital ulcers can cause severe morbidity. Further research is warranted to better define the pathophysiology and optimal management.

References

Jul 15, 1992·Annals of Internal Medicine·A S Indorf, P S Pegram
Oct 1, 1992·The Journal of Infectious Diseases·P R Georghiou, A M Allworth
Oct 23, 1991·JAMA : the Journal of the American Medical Association·H L Minkoff, J A DeHovitz
Feb 3, 1990·Lancet·J W Van Der PijlS A Danner
May 2, 1990·JAMA : the Journal of the American Medical Association·L RabeneckW J Boyko
Jul 1, 1990·American Journal of Obstetrics and Gynecology·J M Covino, W M McCormack
Sep 1, 1989·Reviews of Infectious Diseases·R H Dretler, D B Rausher
Oct 1, 1986·American Journal of Obstetrics and Gynecology·J A MaierM G Ross
Feb 1, 1995·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·D L PatersonR J Kemp
Feb 1, 1995·American Journal of Obstetrics and Gynecology·K D LaGuardiaW J Ledger
Aug 1, 1993·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·R A ClarkC Pindaro
May 1, 1996·American Journal of Obstetrics and Gynecology·P SchumanJ D Sobel

❮ Previous
Next ❯

Citations

Nov 30, 2000·Current Infectious Disease Reports·J D Sobel
Jan 1, 1999·Journal of Nurse-midwifery·A MacLaren, W Imberg
Sep 26, 2003·American Journal of Clinical Dermatology·A Ross Kerr, Jonathan A Ship
Oct 5, 2010·Dermatologic Clinics·Grace D Bandow
Dec 18, 2004·Journal of Pediatric and Adolescent Gynecology·Jonathan D K Trager
Nov 16, 2005·Clinical Obstetrics and Gynecology·Fiona M Lewis, Shireen S Velangi
Feb 5, 2010·Journal of Cutaneous Medicine and Surgery·Kimberly LaiMary Gail Mercurio
Feb 6, 2004·Dermatologic Therapy·Tanja G Bohl

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.