Idiopathic hypertrophic cranial pachymeningitis successfully treated with weekly subcutaneous methotrexate

Acta neurochirurgica
J L Ruiz-SandovalE Chiquete

Abstract

Idiopathic hypertrophic cranial pachymeningitis is a very infrequent disorder. Adequate management is still a matter of debate. We describe the use of low-dose pulse methotrexate in treating a 63-year-old woman with idiopathic hypertrophic cranial pachymeningitis. A weekly scheme with subcutaneous methotrexate was tried. Clinical improvement occurred in one week. Total remission of the clinical and neuro-imaging abnormalities was evident 6 months later, with minimal side effects. The patient is in complete remission after one year of follow-up without treatment. Hence, low-dose weekly subcutaneous methotrexate may be safe and effective in inducing complete and sustained remission of this condition. The experience with subcutaneous methotrexate to treat this entity has never been reported.

References

Oct 1, 1995·Journal of Neurology, Neurosurgery, and Psychiatry·Y Kawano, J Kira
Aug 1, 1993·Journal of Neurosurgery·A N MamelakM L Rosenblum
Aug 10, 2000·Neuropathology : Official Journal of the Japanese Society of Neuropathology·T NagashimaK Nagashima
Aug 2, 2001·Neurology·O H Del BruttoH H García
Aug 16, 2001·The American Journal of Tropical Medicine and Hygiene·H H GarciaUNKNOWN Cysticercosis Working Group in Peru
Nov 5, 2002·European Journal of Radiology·Antonio CanoJosé L Sancho
Jan 23, 2003·Clinical Pharmacokinetics·Jirí GrimJirina Martínková
Mar 10, 2004·Neurology·M J KupersmithH J Mitnick
Aug 18, 2004·Journal of Neurology, Neurosurgery, and Psychiatry·I KleiterA Steinbrecher

❮ Previous
Next ❯

Citations

Jan 26, 2008·Clinical Rheumatology·Masaru TogashiKen-ichi Sawada
Jun 30, 2010·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Shoko M YamadaHitoshi Nakayama
Aug 23, 2011·Journal of Neurosurgery·Eui Hyun KimJong Hee Chang
Mar 23, 2011·Revue neurologique·C H AbouzaidL Essaadouni
Apr 21, 2009·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·R BhatiaK Prasad
Sep 21, 2007·European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society·Ronald van ToornSavvas Andronikou
Jun 13, 2008·Headache·So-Hyang ImJong-Sun Choi
Aug 18, 2020·Current Pain and Headache Reports·Larry Charleston, Wade Cooper
Apr 4, 2017·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Ruofu TangQixin Chen

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.