Idiopathic Inflammatory Myopathies: A Review of the Classification and Impact of Pathogenesis

International Journal of Molecular Sciences
Dana E MandelAli D Askari

Abstract

Idiopathic inflammatory myopathies (IIMs) are a group of autoimmune muscle diseases with significant morbidity and mortality. This review details and updates the pathogenesis and emerging importance of myositis-specific antibodies in the development of IIMs. An increase in the understanding of how these myositis-specific antibodies play a role in IIMs has led to the further categorization of IIMs from the traditional polymyositis versus dermatomyositis, to additional subcategories of IIMs such as necrotizing autoimmune myositis (NAM). The diagnosis of IIMs, including manual muscle testing, laboratory studies, and non-invasive imaging have become important in classifying IIM subtypes and for identifying disease severity. Treatment has evolved from an era where glucocorticoid therapy was the only option to a time now that includes traditional steroid-sparing agents along with immunoglobulin therapy and biologics, such as rituximab.

References

Feb 20, 1975·The New England Journal of Medicine·A Bohan, J B Peter
Feb 13, 1975·The New England Journal of Medicine·A Bohan, J B Peter
Nov 1, 1982·Seminars in Arthritis and Rheumatism·A D Askari, T L Huettner
Sep 27, 2003·Lancet·Marinos C Dalakas, Reinhard Hohlfeld
Jun 19, 2010·Nature·Cristiana GuiducciFranck J Barrat
May 22, 2013·Mediators of Inflammation·Sabino ScollettaClara Crescioli
Jul 3, 2013·North American Journal of Medical Sciences·Khalid RasheedEric Bixby
Aug 24, 2013·Rheumatology·Paulius Venalis, Ingrid E Lundberg
Feb 3, 2015·Muscle & Nerve·Andrew R FindlayTahseen Mozaffar
Apr 30, 2015·The New England Journal of Medicine·Marinos C Dalakas
Aug 14, 2015·International Journal of Molecular Sciences·Boel De Paepe, Jana Zschüntzsch
Aug 28, 2015·Expert Review of Clinical Immunology·Siamak Moghadam-KiaChester V Oddis
Oct 2, 2015·Clinical Reviews in Allergy & Immunology·Minoru SatohEdward K L Chan
Apr 22, 2016·Journal of Internal Medicine·C V Oddis
Apr 28, 2016·JAMA Dermatology·Drew J B KurtzmanRuth Ann Vleugels
Jun 21, 2016·Journal of Internal Medicine·I E Lundberg
Jun 21, 2016·Journal of Internal Medicine·I E LundbergM Bottai
Jul 6, 2016·Frontiers in Immunology·Jean-Philippe SimonJérémie Martinet
Jul 29, 2016·Current Opinion in Rheumatology·Simon RothwellHector Chinoy

❮ Previous
Next ❯

Citations

Oct 20, 2018·Journal of Cachexia, Sarcopenia and Muscle·Francesca RiuzziRosario Donato
Sep 16, 2018·Der Internist·M MahmudO M Steinmetz
Aug 23, 2018·Breathe·Maria BolakiKaterina M Antoniou
Sep 17, 2018·The Journal of Rheumatology·Stanislas FaguerDavid Ribes
May 16, 2019·Molecular Biology Reports·Alexander EmmerMalte Erich Kornhuber
Dec 2, 2020·Neurology International·Bruno CorradoLaura Lucignano
May 26, 2021·Ultrasound in Medicine & Biology·Manuel KolbMarius Horger
Dec 19, 2020·Journal of Clinical Rheumatology : Practical Reports on Rheumatic & Musculoskeletal Diseases·Víctor A SantosAndrés Hormaza-Jaramillo

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsy
biopsies
bronchoalveolar lavage

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Related Papers

Current Opinion in Rheumatology
Rohit Aggarwal, Chester V Oddis
The New England Journal of Medicine
Marinos C Dalakas
Current Rheumatology Reports
Pari Basharat, Lisa Christopher-Stine
© 2022 Meta ULC. All rights reserved