Idiopathic myelofibrosis developing isolated granulocytic sarcoma with der (1;7)(q10; p10) after splenectomy and finally transforming to acute myelogenous leukemia

Leukemia & Lymphoma
S KasaharaH Moriwaki

Abstract

A 47-year-old female with idiopathic myelofibrosis developed isolated granulocytic sarcoma with der (1; 7)(q10; p10) after splenectomy, followed by acute myelogenous leukemia. The patient had myelofibrosis since 22 years of age, received splenectomy at 47 years, and developed isolated submandibular granulocytic sarcoma, 8 months later. Although the initial tumor disappeared after irradiation, recurrent tumors selectively appeared in the areas of operative scars. She subsequently developed blastic transformation with der (1; 7)(q10; p10), and the blasts were refractory to different chemotherapy. This case is very rare in the following aspects: the onset of myelofibrosis occurred at a relatively young age; isolated granulocytic sarcoma after splenectomy preceded the transformation to acute leukemia; and the subcutaneous tumors developed in areas of operative scars.

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Citations

Mar 14, 2003·Surgical Neurology·Sharon W W ChanK W Chan
Oct 24, 2013·Radiation Oncology·Wan-Yu ChenAnn-Lii Cheng
Feb 6, 2016·Journal of Medical Case Reports·Jesus Vera-AguileraCarlos Vera-Aguilera
Feb 21, 2014·Pediatric Hematology and Oncology·Aditya Kumar GuptaAnupam Sachdeva
Aug 19, 2009·American Journal of Clinical Pathology·Cristina CampidelliStefano A Pileri
Oct 19, 2016·The American Journal of Surgical Pathology·Keisuke KawamotoKoichi Ohshima

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