PMID: 2118691Jul 1, 1990Paper

Idiopathic pulmonary fibrosis: can cell mediated immunity markers predict clinical outcome?

Thorax
R MeliconiG Gasbarrini

Abstract

Most of the cells found in lung parenchyma in patients with idiopathic pulmonary fibrosis are activated T lymphocytes and macrophages. The serum levels of three markers of cell mediated immunity were measured in 20 patients with idiopathic pulmonary fibrosis, in 20 normal subjects and in 12 patients with sarcoidosis to evaluate their clinical and prognostic significance in idiopathic pulmonary fibrosis. The three markers were: soluble CD8 (from activated suppressor-cytotoxic lymphocytes), soluble interleukin (IL)-2 receptors (from activated T cells and macrophages), and neopterin (from activated macrophages). Patients with idiopathic pulmonary fibrosis had higher levels of all three markers than the control subjects. Soluble IL-2 receptor and neopterin tended to be lower (though not significantly) in patients with idiopathic pulmonary fibrosis than in those with sarcoidosis, whereas soluble CD8 was similar in the two groups of patients. No correlation was found between soluble IL-2 receptors or soluble CD8 and the clinical, radiological, and physiological measures of disease activity or with clinical outcome (after a mean follow up of 23 months). Tumour necrosis factor levels were also determined. Only 30% of patients with idio...Continue Reading

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Citations

Apr 1, 1995·Journal of Clinical Pathology·M UguccioniR Meliconi
Jan 1, 1996·Mediators of Inflammation·J Müller-Quernheim
Oct 1, 1993·The American Review of Respiratory Disease·D G KernJ C Varone
Aug 1, 2012·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Mahmoud DastooriStephen R Porter
Dec 31, 1997·Clinics in Chest Medicine·U Costabel, H Teschler
Jun 9, 1998·Respiratory Medicine·J Müller-Quernheim
Oct 21, 2005·Respiratory Medicine·Pelagia G TsoutsouPashalis-Adam Molyvdas
Oct 21, 2016·Expert Review of Clinical Immunology·Amit ChopraMarc A Judson
Mar 31, 2017·Immunology and Cell Biology·Gerard F HoyneCecilia M Prêle

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