Idiopathic pulmonary fibrosis: from clinical trials to real-life experiences

European Respiratory Review : an Official Journal of the European Respiratory Society
Sergio Harari, Antonella Caminati

Abstract

Randomised controlled clinical trials are fundamental in medicine to develop new effective drugs and new therapeutic regimens and are the strength of evidence-based medicine. These studies allow us to avoid the repetition of misleading experiences that have been reported in the past, where drugs or associations were utilised without compelling evidence and ultimately proven to be ineffective. In recent years, randomised clinical trials have been conducted and concluded for many rare diseases, including idiopathic pulmonary fibrosis. However, clinical trials do not always reflect the real-life scenario. Patients selected for clinical trials present fewer comorbidities, they fall between certain age limits, and the severity of their disease is defined; therefore, they do not always reflect the whole of the population affected by a specific disease. These are the reasons why we also need data that mirror real-life experience. The limitations that these kind of studies present are always several and the studies should be interpreted with caution, although they can fill the important gap between efficacy and effectiveness. In this article, we will review the existing clinical data on real-life treatment of idiopathic pulmonary fibro...Continue Reading

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Mar 28, 2017·Expert Review of Respiratory Medicine·Keith C Meyer
Sep 13, 2016·European Clinical Respiratory Journal·Goran Nadir SalihElisabeth Bendstrup
Mar 28, 2018·Respiration; International Review of Thoracic Diseases·Sergio HarariUNKNOWN for the ILDINET (Interstitial Lung Diseases Italian Network)
Sep 29, 2017·European Respiratory Review : an Official Journal of the European Respiratory Society·Antonella CaminatiSergio Harari
Feb 25, 2017·The European Respiratory Journal·Michael Kreuter, Vincent Cottin
Sep 2, 2015·European Respiratory Review : an Official Journal of the European Respiratory Society·Sergio HarariVincent Cottin
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Oct 4, 2019·European Respiratory Review : an Official Journal of the European Respiratory Society·Antonella CaminatiSergio Harari

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