Idiopathic pulmonary fibrosis is associated with circulating antiepithelial antibodies.

Lung
Ahmed FahimSimon P Hart

Abstract

Idiopathic pulmonary fibrosis (IPF) is a restrictive fibrotic lung disease of uncertain etiology. Alveolar epithelial injury may be one of the inciting triggers in the pathogenesis of this disorder. We hypothesized that circulating antibodies to alveolar epithelial and endothelial cells may be involved in the pathogenesis of IPF. Antibodies to alveolar epithelial and endothelial cells were analyzed by indirect immunofluorescence using alveolar epithelial cells (A549) and human umbilical vein endothelial cells respectively. IgG and IgM antibodies in patients' serum were evaluated. Patterns of immunofluorescence, including membranous, cytoplasmic, and nuclear staining, were analyzed by fluorescence microscopy. The severity of immunofluorescence was divided into mild, moderate, and severe categories. Fifty-six patients (IPF = 28, non-IPF ILD = 9, non-ILD control = 19) were evaluated for antiepithelial antibodies, and 28 patients (IPF = 12, non-IPF ILD = 3, non-ILD control = 13) were studied for antiendothelial antibodies. Compared with control subjects, serum from IPF patients displayed significantly higher IgG binding to alveolar epithelial cells (P = 0.041) with a membranous pattern of immunofluorescence. However, there was no s...Continue Reading

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Citations

Mar 19, 2013·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Meirong WangChangjun Lv
Feb 1, 2015·American Journal of Physiology. Lung Cellular and Molecular Physiology·Tereza TomankovaMingyao Liu
May 18, 2019·Journal of Immunology Research·Ross MillsNik Hirani

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