Idiopathic Pulmonary Fibrosis Serum proteomic analysis before and after nintedanib therapy.

Scientific Reports
Claudia LandiElena Bargagli

Abstract

Idiopathic pulmonary fibrosis (IPF) is a fatal progressive disease with a median survival of 2-5 years. Nintedanib is a small tyrosine kinase inhibitor that reduces IPF progression, significantly slowing the annual decline in Forced Vital Capacity (FVC). Very little data is available on the molecular mechanisms of this treatment in IPF, despite a growing interest in the definition of IPF pathogenesis and target therapy. A functional proteomic approach was applied to the analysis of serum samples from IPF patients in order to highlight differential proteins potentially indicative of drug-induced molecular pathways modifications and response to therapy. Twelve serum samples were collected from six IPF patients in care at Siena Regional Referral Center for Interstitial Lung Diseases (ILDs) and treated with nintedanib for one year. Serum samples were analyzed at baseline (T0 before starting therapy) and after one year of treatment (T1) and underwent differential proteomic and bioinformatic analysis. Proteomic analysis revealed 13 protein species that were significantly increased after one year of treatment. When the targets of nintedanib (VEGFR, FGFR and PDGFR) were added, enrichment analysis extracted molecular pathways and proces...Continue Reading

References

Jul 5, 2005·The European Respiratory Journal·V BrusascoUNKNOWN European Respiratory Society
Jan 30, 2010·Journal of Aerosol Medicine and Pulmonary Drug Delivery·Philipp MarkartAndreas Guenther
Apr 27, 2010·American Journal of Physiology. Lung Cellular and Molecular Physiology·Harold R CollardDong Soon Kim
Apr 8, 2011·American Journal of Respiratory and Critical Care Medicine·Ganesh RaghuUNKNOWN ATS/ERS/JRS/ALAT Committee on Idiopathic Pulmonary Fibrosis
May 2, 2012·Critical Care : the Official Journal of the Critical Care Forum·Pieter R TuinmanMarcus J Schultz
Aug 6, 2013·Inflammation·E BargagliP Rottoli
Apr 8, 2015·Pathology Oncology Research : POR·Boglárka Erdélyi-BelleLászló Homolya
Aug 8, 2015·Experimental Eye Research·Irene Lee-RiveraAna María López-Colomé
Apr 14, 2016·Respiratory Research·Keishi OdaHiroshi Mukae
Apr 19, 2017·Thorax·H A Baarsma, M Königshoff
Jul 25, 2017·Laboratory Investigation; a Journal of Technical Methods and Pathology·Alvaro BecerraFelipe Simon
Nov 16, 2017·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Wendan YuWuguo Deng
Nov 24, 2017·Cancer Treatment Reviews·Nithya Krishnamurthy, Razelle Kurzrock
Apr 27, 2018·American Journal of Physiology. Lung Cellular and Molecular Physiology·David W WatersDarryl A Knight
Jul 22, 2018·Respiratory Investigation·Hirofumi ChibaHiroki Takahashi
Oct 21, 2018·Respiratory Research·Hee-Young YoonJin Woo Song
Oct 24, 2018·Clinical Hemorheology and Microcirculation·Sonia SalhaSanga Gehmert
Jan 5, 2019·American Journal of Respiratory Cell and Molecular Biology·David W WatersDarryl A Knight
Jan 10, 2019·Immunology Letters·Swathi M RajuSandeepta Burgula
Feb 26, 2019·Respiratory Investigation·Laura BergantiniPaola Rottoli
Jan 24, 2020·Clinical and Experimental Medicine·Miriana d'AlessandroElena Bargagli

❮ Previous
Next ❯

Citations

Aug 14, 2020·International Journal of Molecular Sciences·Elena BargagliClaudia Landi
Oct 20, 2020·Molecular Omics·Tila KhanKoel Chaudhury
Nov 19, 2020·International Journal of Molecular Sciences·Rivka C StoneMarjana Tomic-Canic
Mar 15, 2021·International Immunopharmacology·Miriana d'AlessandroElena Bargagli
Jan 12, 2022·Cellular and Molecular Life Sciences : CMLS·Peiyan ZhengBaoqing Sun

❮ Previous
Next ❯

Methods Mentioned

BETA
bronchoalveolar lavage
ELISA
PCA

Software Mentioned

Mascot
Cluster
GraphPad Prism
Metacore

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.