PMID: 2094140Jan 1, 1990Paper

Idiopathic recurrent spontaneous abortion. Evidence of a familial predisposition

Acta Obstetricia Et Gynecologica Scandinavica
O B ChristiansenN Grunnet

Abstract

Pregnancy outcome was investigated: 1) in fifteen women suffering from idiopathic recurrent spontaneous abortion (RSA) and who had experienced pregnancies with two different partners, and 2) in the mothers, the sisters and wives of the brothers of 90 consecutively referred women with RSA. After adjusting for ascertainment bias, the patients with 2 partners had an abortion rate of 72% with the first spouse (significantly increased compared with the expected rate) and a nearly 100% abortion rate with the second spouse. This suggests that, in the main, RSA is not partner-specific. The sisters of the patients had suffered a significantly increased miscarriage rate (25.3%) compared with the observed rate in a Danish control group. The wives of the brothers had an abortion rate of 18.8%, which was not significantly increased vis-à-vis the controls. The sisters showed a lifetime incidence of RSA (10.6%) which was significantly greater than comparable estimates in the literature. These results suggest the existence of a familial predisposition to spontaneous abortion in families where RSA occurs.

Citations

Aug 10, 2000·Statistics in Medicine·H H HundborgS L Lauritzen
Aug 1, 1995·European Journal of Immunogenetics : Official Journal of the British Society for Histocompatibility and Immunogenetics·O B ChristiansenN Grunnet
May 16, 2014·Human Mutation·Liina NagirnajaMaris Laan
Apr 12, 2005·Fertility and Sterility·Ole B ChristiansenKatrin van der Ven
Feb 7, 2014·Free Radical Research·M B KhadzhievaL E Salnikova
Jan 28, 2012·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Silvana MiskovicJasminka Pavelic
Mar 19, 2019·Reproductive Sciences·Paula Quintero-Ronderos, Paul Laissue
Sep 11, 2018·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·G DryllisM Politou
May 22, 2020·The European Journal of Contraception & Reproductive Health Care : the Official Journal of the European Society of Contraception·A M KolteH S Nielsen
Jun 20, 2020·Acta Obstetricia Et Gynecologica Scandinavica·Andrea M F WoolnerSohinee Bhattacharya
Jan 24, 2019·BMJ Open·Cathrine WildenschildEllen M Mikkelsen
May 21, 2020·Reproductive Sciences·Paula Quintero-Ronderos, Paul Laissue
Nov 27, 2020·Nature Communications·Triin LaiskCecilia M Lindgren
Feb 20, 2021·Current Opinion in Obstetrics & Gynecology·Christina G Tise, Heather M Byers
May 6, 2015·Annals of Internal Medicine·Jean-Christophe Gris

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