Apr 2, 2011

Idiopathic retroperitoneal fibrosis: a retrospective review of clinical presentation, treatment, and outcomes

Mayo Clinic Proceedings
Tanaz A KermaniHarvinder S Luthra

Abstract

To describe the clinical manifestations, laboratory results, imaging findings, and treatments in patients with idiopathic retroperitoneal fibrosis (IRF) seen at Mayo Clinic in Rochester, MN. In this retrospective study, we used International Classification of Diseases, Ninth Revision codes to identify all patients evaluated for IRF between January 1, 1996, and December 31, 2006, at Mayo Clinic in Rochester, MN. Medical records were reviewed, and clinical information was abstracted. Idiopathic retroperitoneal fibrosis was diagnosed on the basis of compatible imaging findings. Patients were followed up until their last visit at Mayo Clinic, death, or December 31, 2008, whichever came first. Of the 185 patients identified as having IRF, 113 (61%) were men and 72 (39%) were women. Mean ± SD age at diagnosis was 57.6 ± 11.8 years. Biopsy specimens were obtained in 142 cases (77%). The most common presenting symptoms were back pain (38%) and abdominal pain (40%). Baseline erythrocyte sedimentation rate and/or C-reactive protein levels were elevated in 88 (58%) of the 151 patients tested. The median creatinine level at diagnosis was 1.3 mg/dL (interquartile range, 1.1-2.1 mg/dL). Fifteen patients (8%) were treated with ureteral proced...Continue Reading

  • References13
  • Citations34

References

  • References13
  • Citations34

Citations

Mentioned in this Paper

Vasculitis
Imaging Studies
Leflunomide
Pathogenic Aspects
Autoantibodies
Kidney Function Tests
Ceroid
Creatinine
Laboratory Studies
Abdominal Cavity

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