Idiopathic short stature: management and growth hormone treatment

Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society
Jan M WitP Cohen

Abstract

In the management of ISS auxological, biochemical, psychosocial and ethical elements have to be considered. In boys with constitutional delay of growth and puberty androgens are effective in increasing height and sexual characteristics, but adult height is unchanged. GH therapy is efficacious in increasing height velocity and adult height, but the inter-individual variation is considerable. The effect on psychosocial status is uncertain. Factors affecting final height gain include GH dose, height deficit in comparison to midparental height, age and first year height velocity. In case of a low predicted adult height at the onset of puberty, addition of a GnRH analogue can be considered. Although GH therapy appears safe, long-term monitoring is recommended.

References

Jul 1, 1992·The Journal of Pediatrics·Z ZadikE Lieberman
Jul 1, 1991·Archives of Disease in Childhood·A PapadimitriouR Stanhope
Oct 1, 1990·Archives of Disease in Childhood·E C CrowneD A Price
Jan 1, 1990·Perspectives in Biology and Medicine·D S Diekema
Apr 1, 1990·Archives of Disease in Childhood·A BuyukgebizC G Brook
Jan 1, 1990·Archives of Disease in Childhood·R D Milner
Apr 15, 1988·Biochemical and Biophysical Research Communications·D D De LeonR G Rosenfeld
Jan 1, 1989·Acta Paediatrica Scandinavica. Supplement·L E Underwood, P A Rieser
Dec 1, 1989·The Journal of Clinical Endocrinology and Metabolism·E E JossK A Zuppinger
Feb 17, 1989·JAMA : the Journal of the American Medical Association·J LantosL Cuttler
Dec 1, 1988·The Journal of Clinical Endocrinology and Metabolism·P TapanainenJ Risteli
Sep 1, 1986·Journal of the American Academy of Child Psychiatry·D A BrentN Conover
Nov 1, 1995·The Journal of Clinical Endocrinology and Metabolism·D T WyattA Slyper
Aug 1, 1995·Journal of Developmental and Behavioral Pediatrics : JDBP·G D ZimetL Cuttler
Apr 1, 1995·The Journal of Clinical Endocrinology and Metabolism·G A TuffliD B Allen
Dec 1, 1994·Acta Paediatrica. Supplement·D SkuseP Hindmarsh
Nov 1, 1994·The Journal of Clinical Endocrinology and Metabolism·D B AllenD Frazier
Oct 20, 1994·The New England Journal of Medicine·E P SmithK S Korach
Mar 1, 1994·The Journal of Clinical Endocrinology and Metabolism·J DiMartino-NardiP Saenger
Mar 1, 1994·The Journal of Clinical Investigation·N MaurasA L Yergey
Feb 1, 1994·Journal of Developmental and Behavioral Pediatrics : JDBP·B StablerL E Underwood
Jan 1, 1993·Hormone Research·E M RitzénJ M Wit

❮ Previous
Next ❯

Citations

Feb 21, 2009·Nature Clinical Practice. Endocrinology & Metabolism·Martin O Savage
Apr 24, 2013·Nature Reviews. Endocrinology·Michael B Ranke
Nov 22, 2013·International Journal of Pediatric Endocrinology·Lindsey A Waldman, Dennis J Chia
Nov 14, 2013·Expert Review of Pharmacoeconomics & Outcomes Research·Neuza SilvaUNKNOWN QoLISSY Group
Sep 29, 2011·Clinical Endocrinology·Ian P HughesUNKNOWN Australasian Paediatric Endocrine Group (APEG)
Apr 20, 2012·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Weirong XingSubburaman Mohan
Oct 29, 2008·Annales d'endocrinologie·F CastinettiT Brue
Jul 31, 2014·International Journal of Pediatric Endocrinology·Juan F Sotos, Naomi J Tokar
Sep 29, 2018·Endocrine Reviews·Helen L StorrVivian Hwa
May 16, 2014·The Journal of Clinical Endocrinology and Metabolism·Berit KriströmUNKNOWN study group
Sep 18, 2008·Arquivos brasileiros de endocrinologia e metabologia·Carlos Alberto Longui
Oct 1, 2018·Hormone Research in Pædiatrics·David B Allen
Apr 18, 2019·Medical Principles and Practice : International Journal of the Kuwait University, Health Science Centre·Nahla KhawajaKamel M Ajlouni

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Metabolism

In order for cancer cells to maintain rapid, uncontrolled cell proliferation, they must acquire a source of energy. Cancer cells acquire metabolic energy from their surrounding environment and utilize the host cell nutrients to do so. Here is the latest research on cancer metabolism.