PMID: 6540530Jan 1, 1984Paper

Idiopathic thrombocytopenic purpura in children. The case for management without corticosteroids

The American Journal of Pediatric Hematology/oncology
J M LusherA I Warrier

Abstract

Acute ITP in children under 13 years of age is generally a benign, self-limited condition with spontaneous recovery occurring within a matter of days or weeks. Our analysis of platelet data indicate no advantage in terms of rate of recovery when steroids are used. In fact, the median of 3 weeks and mean of 3 1/2 weeks from onset to recovery in the nonsteroid-treated children were significantly better than the corresponding figures in the steroid-treated group. In addition, while reducing the risk of intracranial hemorrhage is generally given as the chief therapeutic rationale for using steroids, we have not seen a single case of ICH among 465 consecutive cases of acute ITP in children, the majority (93%) of whom did not receive steroids. On the other hand, adolescents, as adults, with ITP often have the autoimmune (chronic) form of the disease. In this group, corticosteroids may be of at least transient benefit and should be used.

Citations

Mar 1, 1987·European Journal of Pediatrics·G R Buchanan
Aug 7, 2003·Journal of Pediatric Hematology/oncology·Linda J Butros, James B Bussel
Oct 16, 2007·Current Opinion in Hematology·Michael D Tarantino, Paula Hb Bolton-Maggs
Nov 1, 1986·Indian Journal of Pediatrics·I A Warrier
May 1, 1987·Indian Journal of Pediatrics·A Emami
Sep 1, 1995·Clinical Pediatrics·A K Souid, P D Sadowitz
Jan 1, 1990·Pediatric Hematology and Oncology·J S Lilleyman
Nov 13, 2001·Reviews in Clinical and Experimental Hematology·H Gadner
Apr 25, 2002·Journal of Pediatric Hematology/oncology·Hana HrstkováJaroslav Michálek
May 1, 1993·American Journal of Hematology·G M Magbool
Jan 24, 2009·Pediatric Blood & Cancer·George B Segel, Stephen A Feig
Aug 1, 1986·European Journal of Pediatrics·T BeckerC Mueller-Eckhardt
Nov 16, 2004·Journal of Pediatric Hematology/oncology·Somasundaram JayaboseClaudio Sandoval
Apr 19, 2008·Pediatric Blood & Cancer·Maria VranouSophie Aronis
Oct 30, 2004·Hematology/oncology Clinics of North America·Michael D Tarantino, George R Buchanan

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