Idiopathic thrombocytopenic purpura is strongly associated with higher prevalence of aortic valve disease

Annals of Hematology
Fathima HaseefaMehrnoosh Hashemzadeh

Abstract

Aortic valve disease (AVD) has similarities to atherosclerosis in the case of aortic stenosis. The important role of platelet in the pathogenesis of atherosclerosis is known. The goal of this study is to evaluate whether platelet disorders play any role in aortic valve disease. We used patients with idiopathic thrombocytopenic purpura (ITP) for this study. We evaluated any association between ITP and AVD using a large inpatient database. The International Classification of Diseases, Ninth Revision, and Clinical Modification (ICD-9-CM) codes for ITP and AVD from the Nationwide Inpatient Sample (NIS) database were used for this study. Uni- and multivariate analyses were performed on data from 2002 to 2011 to evaluate any association between ITP and AVD. In the 2002 database, AVD was present in 1.73% of ITP patients versus 1.12% in the control population (odds ratio [OR], 1.56; 95% confidence interval [CI], 1.34-1.81; p < 0.001). In the 2011 database, AVD was present in 1.96% of ITP patients versus 1.33% in the control population (OR, 1.48; 95% CI, 1.30-1.68; p < 0.001). ITP remained independently associated with AVD following a multivariate logistic regression analysis adjusting for age, gender, diabetes mellitus, hypertension, a...Continue Reading

References

Aug 1, 1973·British Heart Journal·R J JacobsonJ K Perloff
May 23, 2002·The American Journal of the Medical Sciences·Oren FruchterGiris Jacob
Feb 20, 2004·European Heart Journal·Catherine M Otto
Sep 19, 2006·Lancet·Vuyisile T NkomoMaurice Enriquez-Sarano
Dec 5, 2009·Advances in Hematology·M A Feudjo-TepieN J Robinson
May 4, 2010·Mayo Clinic Proceedings·Kameswari MagantiRobert O Bonow
Jul 24, 2010·International Journal of Hematology·Cheryl EngerAndrew T McAfee
Aug 17, 2012·Circulation. Cardiovascular Interventions·Jane A Leopold
Mar 6, 2013·Journal of Thrombosis and Haemostasis : JTH·N M Htun, K Peter
Apr 3, 2013·Critical Care Nurse·Theresa Cary, Judith Pearce
Aug 5, 2014·Current Opinion in Pediatrics·Robert B Hinton
Oct 22, 2016·British Journal of Haematology·María T Álvarez-RománNora V Butta
Jan 1, 2016·Journal of Geriatric Cardiology : JGC·Neal BhatiaNanette K Wenger
Jul 15, 2017·World Journal of Cardiology·Andrei D Mǎrgulescu
May 16, 2018·Frontiers in Immunology·Maurice SwinkelsA J Gerard Jansen

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