Idiosyncratic rifabutin-induced leukopenia and SIADH: case report and review

Pharmacotherapy
M M Chitre, C S Berenson

Abstract

Rifabutin is increasingly critical for treatment of atypical mycobacterial infections. One of its serious adverse effects is leukopenia. When encountering rifabutin-induced leukopenia, clinicians are faced with the dilemma of whether to lower the dosage of rifabutin or discontinue it because existing literature does not indicate whether rifabutin-induced leukopenia is dose related or idiosyncratic. We report the first established case of idiosyncratic rifabutin-induced leukopenia in an immunocompetent man treated for pulmonary Mycobacterium avium complex infection. The patient also developed rifabutin-induced syndrome of inappropriate antidiuretic hormone (SIADH), which also has not been previously reported.

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Citations

Mar 27, 2009·Nature Reviews. Nephrology·R ZietseE J Hoorn
May 15, 2002·Pharmacoepidemiology and Drug Safety
Aug 13, 2011·The Journal of Infection·George LiamisMoses Elisaf
Jul 22, 2014·The Korean Journal of Internal Medicine·Ji Yeun ChangChul Woo Yang
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Aug 1, 2019·The Annals of Pharmacotherapy·Rachel S BrittChristopher McCoy

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